BACKGROUND: Nanotechnology is rapidly emerging in biomedical applications, including cancer therapy. Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined. MATERIALS AND METHODS: C57BL/6 mice were treated with DPV576-C as a lining in a mouse house for 1 month. Splenic cells were analyzed for CD4(+) and CD8(+) T-cells and NK activity using flow cytometry. RESULTS: DPV576-C-treated aged mice showed an: (1) increase in the percentages of CD4(+) and CD8(+) T-cells and their activation markers, CD25 and CD69, over untreated aged mice; (2) enhancement of NK activity; and (3) absence of adverse side effects as determined histopathologically. CONCLUSION: The enhancement of lymphocytes by DPV576-C may be useful for patients suffering from immune dysfunction.
BACKGROUND: Nanotechnology is rapidly emerging in biomedical applications, including cancer therapy. Here, a mixture of ultra dispersed nanodiamond and nanoplatinum was coated onto fabrics in the form of a cloth (DPV576-C). The role of DPV576-C in modulating T lymphocytes of aged mice was examined. MATERIALS AND METHODS: C57BL/6 mice were treated with DPV576-C as a lining in a mouse house for 1 month. Splenic cells were analyzed for CD4(+) and CD8(+) T-cells and NK activity using flow cytometry. RESULTS:DPV576-C-treated aged mice showed an: (1) increase in the percentages of CD4(+) and CD8(+) T-cells and their activation markers, CD25 and CD69, over untreated aged mice; (2) enhancement of NK activity; and (3) absence of adverse side effects as determined histopathologically. CONCLUSION: The enhancement of lymphocytes by DPV576-C may be useful for patients suffering from immune dysfunction.
Authors: Lorena P Suarez-Kelly; Amanda R Campbell; Isaac V Rampersaud; Ambika Bumb; Min S Wang; Jonathan P Butchar; Susheela Tridandapani; Lianbo Yu; Arfaan A Rampersaud; William E Carson Journal: Nanomedicine Date: 2016-12-18 Impact factor: 5.307
Authors: Mamdooh H Ghoneum; James K Gimzewski; Aya Ghoneum; Hideki Katano; Clarissa Nila Paw U; Anshu Agrawal Journal: Nanomaterials (Basel) Date: 2018-09-29 Impact factor: 5.076