Literature DB >> 20363633

Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.

William Vernier1, Wesley Chong, David Rewolinski, Samantha Greasley, Thomas Pauly, Morena Shaw, Dac Dinh, Rose Ann Ferre, James W Meador, Seiji Nukui, Martha Ornelas, Robert L Paz, Eric Reyner.   

Abstract

A novel series of potent thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV was discovered using structure-based drug design. Synthesis, structure-activity relationship, and optimization of physicochemical properties are described. Low nanomolar potency was achieved, and selected compounds with improved thermodynamic solubility showed promising in vitro inhibition of carbonic anhydrase activity in rabbit iris ciliary body homogenate. (c) 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20363633     DOI： 10.1016/j.bmc.2010.03.014

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.

Authors:  Aurelija Mickevičiūtė; David D Timm; Marius Gedgaudas; Vaida Linkuvienė; Zhiwei Chen; Abdul Waheed; Vilma Michailovienė; Asta Zubrienė; Alexey Smirnov; Edita Čapkauskaitė; Lina Baranauskienė; Jelena Jachno; Jurgita Revuckienė; Elena Manakova; Saulius Gražulis; Jurgita Matulienė; Enrico Di Cera; William S Sly; Daumantas Matulis
Journal:  Eur Biophys J       Date:  2017-10-03       Impact factor: 1.733

2.  Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII.

Authors:  Lina Baranauskienė; Daumantas Matulis
Journal:  BMC Biophys       Date:  2012-06-07       Impact factor: 4.778

3.  A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.

Authors:  Murat Bozdag; Melissa Pinard; Fabrizio Carta; Emanuela Masini; Andrea Scozzafava; Robert McKenna; Claudiu T Supuran
Journal:  J Med Chem       Date:  2014-11-10       Impact factor: 7.446

4.  Iron oxide (Fe3O4) magnetic nanoparticles supported on wrinkled fibrous nanosilica (WFNS) functionalized by biimidazole ionic liquid as an effective and reusable heterogeneous magnetic nanocatalyst for the efficient synthesis of N-sulfonylamidines.

Authors:  Sajjad Azizi; Nasrin Shadjou
Journal:  Heliyon       Date:  2021-01-28

5.  Acipimox inhibits human carbonic anhydrases.

Authors:  Mattia Mori; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

6.  Molecular docking-assisted investigation of Pd(II) complexes carrying "SNS" pincer-type pyridine-thioether ligand as potential drug candidates against COVID-19.

Authors:  Hatice Gamze Sogukomerogullari
Journal:  Comput Biol Med       Date:  2022-04-10       Impact factor: 6.698
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.