| Literature DB >> 20363624 |
P Douglas Boatman1, Thomas O Schrader, Michelle Kasem, Benjamin R Johnson, Philip J Skinner, Jae-Kyu Jung, Jerry Xu, Martin C Cherrier, Peter J Webb, Graeme Semple, Carleton R Sage, Jens Knudsen, Ruoping Chen, Andrew K Taggart, Ester Carballo-Jane, Jeremy G Richman.
Abstract
Tricyclic pyrazole tetrazoles which are potent partial agonists of the high affinity niacin receptor, GPR109a, have been discovered and optimized. One of these compounds has proven to be effective at lowering free fatty acids in vitro and in vivo. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20363624 DOI： 10.1016/j.bmcl.2010.03.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823