| Literature DB >> 20363140 |
Savina Malancona1, Monica Donghi, Marco Ferrara, Josè I Martin Hernando, Marco Pompei, Silvia Pesci, Jesus M Ontoria, Uwe Koch, Michael Rowley, Vincenzo Summa.
Abstract
Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[de]isoquinoline-1,3(2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20363140 DOI： 10.1016/j.bmc.2010.03.024
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641