Literature DB >> 20363133

Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N'-diaryl urea inhibitors of soluble epoxide hydrolase.

Sampath-Kumar Anandan1, Richard D Gless.   

Abstract

The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N'-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20363133     DOI： 10.1016/j.bmcl.2010.03.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties.

Authors:  Shao-Xu Huang; Hui-Yuan Li; Jun-Yan Liu; Christophe Morisseau; Bruce D Hammock; Ya-Qiu Long
Journal:  J Med Chem       Date:  2010-11-11       Impact factor: 7.446

2.  Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.

Authors:  Matthew P Martin; Yunting Luo; Roberta Pireddu; Hua Yang; Harsukh Gevariya; Harshani R Lawrence; Sevil Ozcan; Jin-Yi Zhu; Robert Kendig; Mercedes Rodriguez; Roy Elias; Jin Q Cheng; Saïd M Sebti; Ernst Schonbrunn; Nicholas J Lawrence
Journal:  J Med Chem       Date:  2012-08-30       Impact factor: 7.446

3.  Investigation of the binding mode of 1, 3, 4-oxadiazole derivatives as amide-based inhibitors for soluble epoxide hydrolase (sEH) by molecular docking and MM-GBSA.

Authors:  Leila Karami; Ali Akbar Saboury; Elham Rezaee; Sayyed Abbas Tabatabai
Journal:  Eur Biophys J       Date:  2016-12-07       Impact factor: 1.733

4.  Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase.

Authors:  In-Hae Kim; Yong-Kyu Park; Bruce D Hammock; Kosuke Nishi
Journal:  J Med Chem       Date:  2011-02-21       Impact factor: 7.446

5.  Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase.

Authors:  In-Hae Kim; In-Hee Lee; Hisashi Nishiwaki; Bruce D Hammock; Kosuke Nishi
Journal:  Bioorg Med Chem       Date:  2014-01-03       Impact factor: 3.641

6.  Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase.

Authors:  In-Hae Kim; Kosuke Nishi; Takeo Kasagami; Christophe Morisseau; Jun-Yan Liu; Hsing-Ju Tsai; Bruce D Hammock
Journal:  Bioorg Med Chem Lett       Date:  2012-08-02       Impact factor: 2.823

7.  Design of Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase.

Authors:  Kerstin Hiesinger; Annika Schott; Jan S Kramer; René Blöcher; Finja Witt; Sandra K Wittmann; Dieter Steinhilber; Denys Pogoryelov; Jana Gerstmeier; Oliver Werz; Ewgenij Proschak
Journal:  ACS Med Chem Lett       Date:  2019-10-30       Impact factor: 4.345

8.  Design, synthesis and biological evaluation of 4-benzamidobenzoic Acid hydrazide derivatives as novel soluble epoxide hydrolase inhibitors.

Authors:  Elham Rezaee Zavareh; Mahdi Hedayati; Laleh Hoghooghi Rad; Soraya Shahhosseini; Mehrdad Faizi; Sayyed Abbas Tabatabai
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696
  8 in total

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