| Literature DB >> 20363129 |
Seung Hyun Kim1, Jung Hyun Park, Tae Bum Kim, Hyang Hwa Lee, Ki Yong Lee, Young Choong Kim, Sang Hyun Sung.
Abstract
The methanolic extract of the bark of Betula platyphylla was found to suppress antigen mediated degranulation of RBL-2H3 cells. Four arylbutanoids (1-4) and eight diarylhepatonoids (5-12) were isolated from the methanolic extract using bioassay-guided fractionation. Among them, compounds 4 and 12 were isolated and assigned for the first time. Compounds 1, 2, 3, 5, 10, and 12 showed remarkable inhibitory activity against the degranulation of RBL-2H3 by antigen stimulation in a dose dependent manner at the concentrations ranging from 10 microM to 100 microM. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20363129 DOI： 10.1016/j.bmcl.2010.03.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823