Literature DB >> 20363128

Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.

Diane H Boschelli1, Daniel Wang, Yan Wang, Biqi Wu, Erick E Honores, Ana Carolina Barrios Sosa, Inder Chaudhary, Jennifer Golas, Judy Lucas, Frank Boschelli.   

Abstract

The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC(50) values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study. 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20363128     DOI： 10.1016/j.bmcl.2010.03.025

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Discriminating of ATP competitive Src kinase inhibitors and decoys using self-organizing map and support vector machine.

Authors:  Aixia Yan; Xiaoying Hu; Kai Wang; Jing Sun
Journal:  Mol Divers       Date:  2012-11-02       Impact factor: 2.943

2.  4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities.

Authors:  Ali Rafinejad; Asal Fallah-Tafti; Rakesh Tiwari; Amir Nasrolahi Shirazi; Deendayal Mandal; Abbas Shafiee; Keykavous Parang; Alireza Foroumadi; Tahmineh Akbarzadeh
Journal:  Daru       Date:  2012-12-26       Impact factor: 3.117
  2 in total

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