| Literature DB >> 20363124 |
Dirce L Komura1, Elaine R Carbonero, Ana Helena P Gracher, Cristiane H Baggio, Cristina S Freitas, Rodrigo Marcon, Adair R S Santos, Philip A J Gorin, Marcello Iacomini.
Abstract
Fucogalactans from Agaricus brasiliensis (EPF-Ab) and A. bisporus var. hortensis (EPF-Ah) were prepared via by aqueous extraction and a purification procedure. EPF-Ab had M(w) 19.4 x 10(3)g/mol and EPF-Ah M(w) 31.1 x 10(3)g/mol. EPF-Ab had a (1-->6)-linked alpha-D-Galp main-chain partially substituted in O-2 by non-reducing end-units of alpha-L-Fucp. EPF-Ah had a similar main-chain with O-2 substitution, but was partially methylated at HO-3, as well as having 2.5% non-reducing end-units of beta-D-Gal. In mice, EPF-Ab gave 39% antinociceptive inhibition (ID(50)>100mg/kg) and no anti-inflammatory activity. EPF-Ah also gave an inhibition of 39% at ID(50) 0.33 mg/kg and also inhibited by 61% (ID(50) 5.0mg/kg) total cell migration and by 32% peritoneal capillary permeability, which is related to the anti-inflammatory effect. The small differences in chemical structure in these polysaccharides thus modified their biological activities. (c) 2010. Published by Elsevier Ltd.Entities:
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Year: 2010 PMID： 20363124 DOI： 10.1016/j.biortech.2010.01.142
Source DB: PubMed Journal: Bioresour Technol ISSN： 0960-8524 Impact factor: 9.642