OBJECTIVE: To appreciate the several head and neck manifestations of Langherans' cell histiocytosis (LCH) in children and their multidisciplinary management and outcome. STUDY DESIGN: Retrospective study. PATIENTS AND METHODS: Clinical reports of 42 patients with LCH treated in the Departments of Paediatric Haematology, Paediatric Oncology and Paediatric Otorhinolaryngology of a tertiary care center were analyzed. Only cases where the disease was localized to the head and neck were considered. The age at diagnosis, gender, clinical presentation, extension of disease as well as response to treatment and outcome were recorded from the charts of each of these patients. RESULTS: Of the 42 patient charts reviewed, 31 (73.8%) presented with head and neck localization. 10 of these had an exclusive head and neck presentation. Multisystem LCH was mostly found in infants under 3-year-old (mean age: 2-year-old), and bony manifestations in older. All treatments delivered to patients were well-tolerated and the evolution good. DISCUSSION AND CONCLUSION: Head and neck involvement is known to be very frequent in LCH. There is no consensus about treatment but authors highlight that all teams in charge of patients presenting with LCH agree to remain as conservative as possible. For solitary large lesions looking like a tumor which resection could result in functional or cosmetic morbidity, it would be important to get first a biopsy. For multisystemic LHC, therapeutic trials with chemotherapy agents still in process should increase the rate of success. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
RCT Entities:
OBJECTIVE: To appreciate the several head and neck manifestations of Langherans' cell histiocytosis (LCH) in children and their multidisciplinary management and outcome. STUDY DESIGN: Retrospective study. PATIENTS AND METHODS: Clinical reports of 42 patients with LCH treated in the Departments of Paediatric Haematology, Paediatric Oncology and Paediatric Otorhinolaryngology of a tertiary care center were analyzed. Only cases where the disease was localized to the head and neck were considered. The age at diagnosis, gender, clinical presentation, extension of disease as well as response to treatment and outcome were recorded from the charts of each of these patients. RESULTS: Of the 42 patient charts reviewed, 31 (73.8%) presented with head and neck localization. 10 of these had an exclusive head and neck presentation. Multisystem LCH was mostly found in infants under 3-year-old (mean age: 2-year-old), and bony manifestations in older. All treatments delivered to patients were well-tolerated and the evolution good. DISCUSSION AND CONCLUSION: Head and neck involvement is known to be very frequent in LCH. There is no consensus about treatment but authors highlight that all teams in charge of patients presenting with LCH agree to remain as conservative as possible. For solitary large lesions looking like a tumor which resection could result in functional or cosmetic morbidity, it would be important to get first a biopsy. For multisystemic LHC, therapeutic trials with chemotherapy agents still in process should increase the rate of success. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Natália Rocha Bedran; Román Carlos; Bruno Augusto Benevenuto de Andrade; Ana Paula Silva Bueno; Mário José Romañach; Cristiane Bedran Milito Journal: Head Neck Pathol Date: 2017-11-21
Authors: Fábio Vieira de Miranda; William Phillip Pereira da Silva; Renato Victor de Oliveira; Gustavo Antônio Correia Momesso; Tárik Ocon Braga Polo; Leonardo Pérez Faverani Journal: Rev Bras Ter Intensiva Date: 2019-10-14
Authors: Francesca Granata; Rosa Morabito; Giovanni Grasso; Elisabetta Alafaci; Francesco M Salpietro; Concetta Alafaci Journal: Surg Neurol Int Date: 2016-03-30