| Literature DB >> 20362961 |
E L A F van Houten1, A P N Themmen, J A Visser.
Abstract
In this review, the role of anti-Müllerian hormone (AMH) as a regulator and marker of ovarian function is described. Studies in mice showed that AMH is one of the intra-ovarian growth factors regulating primordial follicle recruitment and follicle-stimulating hormone (FSH) sensitivity of growing follicles in an inhibitory manner. Association studies of common variants of the AMH and AMHRII gene suggest that AMH may have a similar role in the human ovary. When it was discovered that serum levels AMH are correlated with the number of growing follicles, AMH gained further clinical interest as a marker for the quantitative aspect of ovarian reserve and as a diagnostic marker for polycystic ovary syndrome (PCOS). Copyright 2010 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2010 PMID： 20362961 DOI： 10.1016/j.ando.2010.02.016
Source DB: PubMed Journal: Ann Endocrinol (Paris) ISSN： 0003-4266 Impact factor: 2.478