PURPOSE: To compare the effects of fluidic parameters on the central corneal thickness (CCT), corneal endothelium, and anterior segment inflammation after phacoemulsification with longitudinal ultrasound. SETTING: Iladevi Cataract & IOL Research Center, Ahmedabad, India. METHODS: In this prospective randomized patient- and examiner-masked study, consecutive patients with age-related cataract were randomly assigned to Group 1 (low fluidic parameters: aspiration flow rate 25 cc/min; bottle height 70 cm and 90 cm; vacuum <or=400 mm Hg) or Group 2 (high fluidic parameters: aspiration flow rate 40 cc/min, bottle height 90 cm and 110 cm; vacuum <or=650 mm Hg). The rate of change in CCT and endothelial cell density (ECD), the incidence of anterior segment inflammation, and corneal clarity were compared between groups. RESULTS: The mean change in CCT from preoperatively to 1 day postoperatively was -6.49% +/- 2.7% in Group 1 and -13.44% +/- 4.3% in Group 2 and from preoperatively to 7 days, -1.74% +/- 1.3% microm and -5.55% +/- 4.3%, respectively (both P<.001). There was no statistically significant difference in the rate of change in ECD between groups from preoperatively to 3 months postoperatively (4.67% +/- 0.15% versus -5.22% +/- 2.84% (P = .45). Anterior chamber flare, cells, and corneal clarity at 1 day were significantly better in Group 1 than in Group 2. CONCLUSION: Low fluidic parameters led to a lower increase in CCT 1 day and 7 days postoperatively, decreased anterior segment inflammation at 1 day, and yielded clear corneas. Copyright (c) 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.
RCT Entities:
PURPOSE: To compare the effects of fluidic parameters on the central corneal thickness (CCT), corneal endothelium, and anterior segment inflammation after phacoemulsification with longitudinal ultrasound. SETTING: Iladevi Cataract & IOL Research Center, Ahmedabad, India. METHODS: In this prospective randomized patient- and examiner-masked study, consecutive patients with age-related cataract were randomly assigned to Group 1 (low fluidic parameters: aspiration flow rate 25 cc/min; bottle height 70 cm and 90 cm; vacuum <or=400 mm Hg) or Group 2 (high fluidic parameters: aspiration flow rate 40 cc/min, bottle height 90 cm and 110 cm; vacuum <or=650 mm Hg). The rate of change in CCT and endothelial cell density (ECD), the incidence of anterior segment inflammation, and corneal clarity were compared between groups. RESULTS: The mean change in CCT from preoperatively to 1 day postoperatively was -6.49% +/- 2.7% in Group 1 and -13.44% +/- 4.3% in Group 2 and from preoperatively to 7 days, -1.74% +/- 1.3% microm and -5.55% +/- 4.3%, respectively (both P<.001). There was no statistically significant difference in the rate of change in ECD between groups from preoperatively to 3 months postoperatively (4.67% +/- 0.15% versus -5.22% +/- 2.84% (P = .45). Anterior chamber flare, cells, and corneal clarity at 1 day were significantly better in Group 1 than in Group 2. CONCLUSION: Low fluidic parameters led to a lower increase in CCT 1 day and 7 days postoperatively, decreased anterior segment inflammation at 1 day, and yielded clear corneas. Copyright (c) 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.