| Literature DB >> 20362629 |
Gorka Larrinaga1, Itxaro Perez, Lorena Blanco, José I López, Leire Andrés, Carmen Etxezarraga, Francisco Santaolalla, Aitor Zabala, Adolfo Varona, Jon Irazusta.
Abstract
Prolyl endopeptidase (EC 3.4.21.26) (PEP) is a serine peptidase that converts several biologically active peptides. This enzyme has been linked to several neurological, digestive, cardiovascular and infectous disorders. However, little is known about its involvement in neoplastic processes. This study analyzes fluorimetrically cytosolic and membrane-bound PEP activity in a large series (n=122) of normal and neoplastic tissues from the kidney, colon, oral cavity, larynx, thyroid gland and testis. Cytosolic PEP activity significantly increased in clear cell renal cell carcinoma, urothelial carcinoma of the renal pelvis and head and neck squamous cell carcinoma. Both cytosolic and membrane-bound PEP activity were also increased in colorectal adenomatous polyps. These data suggest the involvement of PEP in some mechanisms that underlie neoplastic processes. Copyright (c) 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20362629 DOI： 10.1016/j.regpep.2010.03.012
Source DB: PubMed Journal: Regul Pept ISSN： 0167-0115