Literature DB >> 20362335

Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Ana Belén Galván1, Mar Mallo, Leonor Arenillas, Marta Salido, Blanca Espinet, Carmen Pedro, Lourdes Florensa, Sergi Serrano, Francesc Solé.   

Abstract

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Year:  2010        PMID： 20362335     DOI： 10.1016/j.leukres.2010.03.022

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  4 in total

1.  Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.

Authors:  Andres Jerez; Yuka Sugimoto; Hideki Makishima; Amit Verma; Anna M Jankowska; Bartlomiej Przychodzen; Valeria Visconte; Ramon V Tiu; Christine L O'Keefe; Azim M Mohamedali; Austin G Kulasekararaj; Andrea Pellagatti; Kathy McGraw; Hideki Muramatsu; Alison R Moliterno; Mikkael A Sekeres; Michael A McDevitt; Seiji Kojima; Alan List; Jacqueline Boultwood; Ghulam J Mufti; Jaroslaw P Maciejewski
Journal:  Blood       Date:  2012-05-02       Impact factor: 22.113

Review 2.  The progress of early growth response factor 1 and leukemia.

Authors:  Jing Tian; Ziwei Li; Yang Han; Tao Jiang; Xiaoming Song; Guosheng Jiang
Journal:  Intractable Rare Dis Res       Date:  2016-05

3.  Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q).

Authors:  Rui Zhang; Young-Mi Kim; Xianfu Wang; Yan Li; Xianglan Lu; Andrea R Sternenberger; Shibo Li; Ji-Yun Lee
Journal:  Int J Med Sci       Date:  2015-09-01       Impact factor: 3.738

4.  TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

Authors:  Detlef Haase; Kristen E Stevenson; Donna Neuberg; Jaroslaw P Maciejewski; Aziz Nazha; Mikkael A Sekeres; Benjamin L Ebert; Guillermo Garcia-Manero; Claudia Haferlach; Torsten Haferlach; Wolfgang Kern; Seishi Ogawa; Yasunobu Nagata; Kenichi Yoshida; Timothy A Graubert; Matthew J Walter; Alan F List; Rami S Komrokji; Eric Padron; David Sallman; Elli Papaemmanuil; Peter J Campbell; Michael R Savona; Adam Seegmiller; Lionel Adès; Pierre Fenaux; Lee-Yung Shih; David Bowen; Michael J Groves; Sudhir Tauro; Michaela Fontenay; Olivier Kosmider; Michal Bar-Natan; David Steensma; Richard Stone; Michael Heuser; Felicitas Thol; Mario Cazzola; Luca Malcovati; Aly Karsan; Christina Ganster; Eva Hellström-Lindberg; Jacqueline Boultwood; Andrea Pellagatti; Valeria Santini; Lynn Quek; Paresh Vyas; Heinz Tüchler; Peter L Greenberg; Rafael Bejar
Journal:  Leukemia       Date:  2019-01-11       Impact factor: 12.883
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.