Literature DB >> 20362331

Expression of syncytin in leukemia and lymphoma cells.

Yi Sun1, Dong-Yun Ouyang, Wei Pang, Yuan-Quan Tu, Yu-Ye Li, Xiao-Mei Shen, Siu-Cheung Tam, Hong-Ying Yang, Yong-Tang Zheng.   

Abstract

Syncytin is a placenta-specific protein and generally believed to play a pivotal role in syncytiotrophoblast morphogenesis. In this study, transcripts of this gene were quantified by real-time RT-PCR and the translated products were measured by an indirect immunofluorescence assay. Results showed that syncytin was found to be expressed in all nine leukemia and lymphoma cell lines studied albeit at different levels and in 43 peripheral blood samples of 57 leukemia or lymphoma patients. Neither the transcripts nor the translated syncytin was detected in blood samples of normal individuals. In conclusion, peripheral blood syncytin may serve as a marker for leukemia and lymphoma. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20362331     DOI： 10.1016/j.leukres.2010.03.016

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  15 in total

1.  HBV X Protein induces overexpression of HERV-W env through NF-κB in HepG2 cells.

Authors:  Cong Liu; Lijuan Liu; Xiuling Wang; Youyi Liu; Miao Wang; Fan Zhu
Journal:  Virus Genes       Date:  2017-06-20       Impact factor: 2.332

2.  Human endogenous retroviral syncytin exerts inhibitory effect on invasive phenotype of B16F10 melanoma cells.

Authors:  Hongbo Mo; Dongyun Ouyang; Lihui Xu; Qi Gao; Xianhui He
Journal:  Chin J Cancer Res       Date:  2013-10       Impact factor: 5.087

Review 3.  Human endogenous retrovirus regulates the initiation and progression of cancers (Review).

Authors:  Srishti Sahu; Bharat Singh; Ambak Kumar Rai
Journal:  Mol Clin Oncol       Date:  2022-08-03

4.  Microarray-based sketches of the HERV transcriptome landscape.

Authors:  Philippe Pérot; Nathalie Mugnier; Cécile Montgiraud; Juliette Gimenez; Magali Jaillard; Bertrand Bonnaud; François Mallet
Journal:  PLoS One       Date:  2012-06-28       Impact factor: 3.240

5.  Close to the Bedside: A Systematic Review of Endogenous Retroviruses and Their Impact in Oncology.

Authors:  David F Grabski; Yinin Hu; Monika Sharma; Sara K Rasmussen
Journal:  J Surg Res       Date:  2019-03-29       Impact factor: 2.417

6.  Upregulation of Leukocytic Syncytin-1 in Acute Myeloid Leukemia Patients.

Authors:  Yi Sun; Hongyan Zhu; Jianxin Song; Yaxian Jiang; Hongmei Ouyang; Rongzhong Huang; Guiqian Zhang; Xin Fan; Rui Tao; Jie Jiang; Hua Niu
Journal:  Med Sci Monit       Date:  2016-07-09

7.  Reduced syncytin-1 expression levels in placental syndromes correlates with epigenetic hypermethylation of the ERVW-1 promoter region.

Authors:  Matthias Ruebner; Pamela L Strissel; Arif B Ekici; Elisabeth Stiegler; Ulf Dammer; Tamme W Goecke; Florian Faschingbauer; Fabian B Fahlbusch; Matthias W Beckmann; Reiner Strick
Journal:  PLoS One       Date:  2013-02-14       Impact factor: 3.240

8.  Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets.

Authors:  Pamela L Strissel; Matthias Ruebner; Falk Thiel; David Wachter; Arif B Ekici; Friedericke Wolf; Franziska Thieme; Klemens Ruprecht; Matthias W Beckmann; Reiner Strick
Journal:  Oncotarget       Date:  2012-10

9.  Promoter Hypermethylation and Decreased Expression of Syncytin-1 in Pancreatic Adenocarcinomas.

Authors:  Qinsheng Lu; Jinping Li; Christopher Senkowski; Zuoqing Tang; Jianhao Wang; Tianhe Huang; Xue Wang; Karen Terry; Steven Brower; Wayne Glasgow; Haibin Chen; Shi-Wen Jiang
Journal:  PLoS One       Date:  2015-07-31       Impact factor: 3.240

Review 10.  The Dark Side of Cell Fusion.

Authors:  Daniel Bastida-Ruiz; Kylie Van Hoesen; Marie Cohen
Journal:  Int J Mol Sci       Date:  2016-04-28       Impact factor: 5.923
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