| Literature DB >> 20362278 |
Jung-Bum Lee1, Yuko Ohta, Kyoko Hayashi, Toshimitsu Hayashi.
Abstract
A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1beta, IL-6, IL-10 and TNF-alpha. Therefore, it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20362278 DOI： 10.1016/j.carres.2010.02.026
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104