OBJECTIVE: To evaluate the type, frequency, and severity of macroscopic small bowel mucosal injury after chronic NSAID intake as assessed by capsule endoscopy (CE), as well as to correlate the severity of gastroduodenal and intestinal damage in these patients. MATERIAL AND METHODS: A prospective, endoscopist-blind, controlled trial. Sixteen patients (14F/2M; age: 57.06 +/- 10.16 yrs) with osteoarthritis (OA) on chronic therapy with NSAIDs underwent CE and uppergastrointestinal endoscopy (UGE). Seventeen patients with OA (9F/2M; age: 57.47 +/- 9.82 yrs) who did not take NSAIDs were included as a control group. A scale ranging from 0 to 2 (0 = no lesions, 1-minor = red spots or petechiae, denuded areas and/or 1-5 mucosal breaks; 2-major = > 5 mucosal breaks and/or strictures, or hemorrhage) was designed to assess the severity of small bowel mucosal injuries. RESULTS: CE found intestinal lesions in 75% (12/16) of patients in the study group and in 11.76% (2/17) of controls (p < 0.01). Seven out of 16 NSAID consumers (43.75%) and none in the control group (0%) had a major small bowel mucosal injury (p < 0.01). The percentages of patients with grade 1 and 2 gastroduodenopathy in the study group, as assessed by UGE, were 37.14 and 23.81%, respectively. There was no significant difference in the rate of major enteropathy between patients with none or minor gastroduodenal injury, and those with major gastroduodenopathy (43.75 vs. 40%; p = N.S.). CONCLUSIONS: Chronic NSAID intake is associated with a high rate of small bowel mucosal injuries. Our data have failed to demonstrate a relationship between the severity of gastroduodenal and intestinal injury.
RCT Entities:
OBJECTIVE: To evaluate the type, frequency, and severity of macroscopic small bowel mucosal injury after chronic NSAID intake as assessed by capsule endoscopy (CE), as well as to correlate the severity of gastroduodenal and intestinal damage in these patients. MATERIAL AND METHODS: A prospective, endoscopist-blind, controlled trial. Sixteen patients (14F/2M; age: 57.06 +/- 10.16 yrs) with osteoarthritis (OA) on chronic therapy with NSAIDs underwent CE and upper gastrointestinal endoscopy (UGE). Seventeen patients with OA (9F/2M; age: 57.47 +/- 9.82 yrs) who did not take NSAIDs were included as a control group. A scale ranging from 0 to 2 (0 = no lesions, 1-minor = red spots or petechiae, denuded areas and/or 1-5 mucosal breaks; 2-major = > 5 mucosal breaks and/or strictures, or hemorrhage) was designed to assess the severity of small bowel mucosal injuries. RESULTS: CE found intestinal lesions in 75% (12/16) of patients in the study group and in 11.76% (2/17) of controls (p < 0.01). Seven out of 16 NSAID consumers (43.75%) and none in the control group (0%) had a major small bowel mucosal injury (p < 0.01). The percentages of patients with grade 1 and 2 gastroduodenopathy in the study group, as assessed by UGE, were 37.14 and 23.81%, respectively. There was no significant difference in the rate of major enteropathy between patients with none or minor gastroduodenal injury, and those with major gastroduodenopathy (43.75 vs. 40%; p = N.S.). CONCLUSIONS: Chronic NSAID intake is associated with a high rate of small bowel mucosal injuries. Our data have failed to demonstrate a relationship between the severity of gastroduodenal and intestinal injury.
Authors: Panagiotis Tsibouris; Chissostomos Kalantzis; Periklis Apostolopoulos; Antonios Zalonis; Peter Edward Thomas Isaacs; Mark Hendrickse; Georgios Alexandrakis Journal: World J Gastrointest Endosc Date: 2014-12-16
Authors: Javier Romero-Vázquez; Federico Argüelles-Arias; Josefa Maria García-Montes; Ángel Caunedo-Álvarez; Francisco Javier Pellicer-Bautista; Juan Manuel Herrerías-Gutiérrez Journal: World J Gastroenterol Date: 2014-06-21 Impact factor: 5.742
Authors: Canaan M Whitfield-Cargile; Noah D Cohen; Robert S Chapkin; Brad R Weeks; Laurie A Davidson; Jennifer S Goldsby; Carrie L Hunt; Shelby H Steinmeyer; Rani Menon; Jan S Suchodolski; Arul Jayaraman; Robert C Alaniz Journal: Gut Microbes Date: 2016-03-23
Authors: Tiago Cúrdia Gonçalves; Mara Barbosa; Bruno Rosa; Maria João Moreira; José Cotter Journal: World J Gastroenterol Date: 2016-10-14 Impact factor: 5.742
Authors: Javier Romero-Vázquez; Ángel Caunedo-Álvarez; Alba Belda-Cuesta; Victoria Alejandra Jiménez-García; Francisco Pellicer-Bautista; Juan Manuel Herrerías-Gutiérrez Journal: Endosc Int Open Date: 2016-09-14
Authors: Ilja Tachecí; Petr Bradna; Tomáš Douda; Drahomíra Baštecká; Marcela Kopáčová; Stanislav Rejchrt; Martin Lutonský; Tomáš Soukup; Jan Bureš Journal: Rheumatol Int Date: 2016-08-22 Impact factor: 2.631