| Literature DB >> 2035982 |
S I Taylor1, D Accili, A Cama, E Imano, H Kadowaki, T Kadowaki.
Abstract
Insulin resistance is an important feature in the pathogenesis of non-insulin-dependent diabetes mellitus. Some rare patients have syndromes associated with a severe form of insulin resistance, usually involving acanthosis nigricans and, in premenopausal females, hyperandrogenism. This review discusses two of the causes of insulin resistance: mutations in the insulin receptor gene and autoantibodies directed against the insulin receptor.Entities:
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Year: 1991 PMID： 2035982 DOI： 10.1146/annurev.me.42.020191.002105
Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739