Literature DB >> 20359751

The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans.

Yanlei Du1, Min Yang, Hung-Wen Yeh, Yu-Jui Yvonne Wan.   

Abstract

In this study, the variable number tandem repeats (VNTR) polymorphism of a 48-bp sequence located in exon 3 of the dopamine receptor D4 (DRD4) gene was genotyped in 365 alcoholic and 337 non-alcoholic Mexican Americans. Logistic regression showed that genotypes without the 7-repeat allele were risk factors for alcoholism. However, linear regression did not find an association between DRD4 VNTR and MAXDRINKS, which was defined as the maximum number of drinks consumed within 24h. Our results indicate the presence of an association between DRD4 VNTR and alcoholism in Mexican Americans. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID： 20359751      PMCID： PMC2868944          DOI： 10.1016/j.psychres.2010.02.021

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  11 in total

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Review 9.  The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review.

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10.  The human dopamine D4 receptor repeat sequences modulate expression.

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