S Nguyen1, S Leroy, C Cracowski, T Perez, M Valette, R Neviere, B Aguilaniu, B Wallaert. 1. Service de pneumologie et immunoallergologie, centre de ressources et de compétence pour la mucoviscidose adulte, clinique des maladies respiratoires, hôpital Albert-Calmette, CHRU de Lille, 59037 Lille cedex, France.
Abstract
BACKGROUND: Current guidelines for referring cystic fibrosis (CF) patients for lung transplantation, based on resting parameters, are insufficient to predict 3-year mortality. The aim of this study was to determine the prognostic value of cardiopulmonary exercise testing (CPET) in adult CF patients. METHODS: A multicenter retrospective study on 3-year outcomes was made on 51 adult CF patients who underwent CPET with blood gas analysis. Demographic data, resting pulmonary function and CPET parameters were collected to perform a univariate survival analysis by Kaplan-Meier curves and log-rank tests. To estimate prognosis, a multivariate logistic regression analysis was performed. RESULTS: The survival log-rank analysis indicated that lower FEV(1), lower body mass index (BMI), diabetes mellitus, lower work rate and higher alveolar-arterial gradient for oxygen (P[A-a]O(2)) at peak exercise were associated with a significantly higher risk of death. The logistic regression analysis showed that BMI (<19.8) and P(A-a)O(2) peak (>43 mmHg) were independently associated with a lower chance of survival. CONCLUSION: CPET with blood gas analysis may have a prognostic value in adult CF patients. Further larger prospective clinical studies are warranted to confirm these preliminary results. Copyright 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.
BACKGROUND: Current guidelines for referring cystic fibrosis (CF) patients for lung transplantation, based on resting parameters, are insufficient to predict 3-year mortality. The aim of this study was to determine the prognostic value of cardiopulmonary exercise testing (CPET) in adult CFpatients. METHODS: A multicenter retrospective study on 3-year outcomes was made on 51 adult CFpatients who underwent CPET with blood gas analysis. Demographic data, resting pulmonary function and CPET parameters were collected to perform a univariate survival analysis by Kaplan-Meier curves and log-rank tests. To estimate prognosis, a multivariate logistic regression analysis was performed. RESULTS: The survival log-rank analysis indicated that lower FEV(1), lower body mass index (BMI), diabetes mellitus, lower work rate and higher alveolar-arterial gradient for oxygen (P[A-a]O(2)) at peak exercise were associated with a significantly higher risk of death. The logistic regression analysis showed that BMI (<19.8) and P(A-a)O(2) peak (>43 mmHg) were independently associated with a lower chance of survival. CONCLUSION: CPET with blood gas analysis may have a prognostic value in adult CFpatients. Further larger prospective clinical studies are warranted to confirm these preliminary results. Copyright 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.
Authors: K Tsiroukidou; M Papagianni; E Hatziagorou; A Galli-Tsinopoulou; A Giannopoulos; I Tsanakas Journal: Hippokratia Date: 2017 Jul-Sep Impact factor: 0.471
Authors: Kristof Vandekerckhove; Michiel Keyzer; Jasper Cornette; Ilse Coomans; Filip Pyl; Frans De Baets; Petra Schelstraete; Filomeen Haerynck; Daniel De Wolf; Sabine Van Daele; Jan Boone Journal: Eur J Pediatr Date: 2017-09-30 Impact factor: 3.183