| Literature DB >> 20359170 |
Laëtitia Palais1, Lucille Babel, Adrien Quintard, Sébastien Belot, Alexandre Alexakis.
Abstract
The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.Entities:
Year: 2010 PMID： 20359170 DOI： 10.1021/ol100441r
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005