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Literature DB >> 20358487

The role of the PTEN gene in malignant gliomas.

Abstract

This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.

Entities: Disease Gene

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Year: 2010 PMID： 20358487 DOI： 10.1016/s0028-3843(14)60408-4

Source DB: PubMed Journal: Neurol Neurochir Pol ISSN： 0028-3843 Impact factor: 1.621

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Cited

8 in total

1. Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis.

Authors: Wei-Zhong Xiao; Dong-Hua Han; Fei Wang; Yong-Qian Wang; You-Hou Zhu; Yi-Fang Wu; Ning-Tao Liu; Ji-Yong Sun
Journal: Tumour Biol Date: 2014-04-08

2. Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.

Authors: Norah E Franklin; Gregory S Taylor; Panayiotis O Vacratsis
Journal: J Biol Chem Date: 2011-03-03 Impact factor: 5.157

3. miR-92b regulates glioma cells proliferation, migration, invasion, and apoptosis via PTEN/Akt signaling pathway.

Authors: Hang Song; Yao Zhang; Na Liu; Chao Wan; Dongdong Zhang; Sheng Zhao; Yan Kong; Liudi Yuan
Journal: J Physiol Biochem Date: 2016-02-18 Impact factor: 4.158

4. PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells.

Authors: Ru-Bin Cheng; Rui-Juan Ma; Zhao-Kai Wang; Shan-Jun Yang; Xiang-Zhi Lin; Hui Rong; Yong Ma
Journal: Mol Cell Biochem Date: 2010-11-26 Impact factor: 3.396

The role of the PTEN gene in malignant gliomas.

1. Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis.

2. Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.

3. miR-92b regulates glioma cells proliferation, migration, invasion, and apoptosis via PTEN/Akt signaling pathway.

4. PTEN status is related to cell proliferation and self-renewal independent of CD133 phenotype in the glioma-initiating cells.

5. Overexpression of SASH1 related to the decreased invasion ability of human glioma U251 cells.

6. A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease.

7. Clinical Significance of SASH1 Expression in Glioma.

8. PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway.