BACKGROUND: Patients with chronic heart failure (HF) have cognitive deficits in memory, psychomotor speed, and executive function and poor health-related quality of life (HRQL), but the association between cognitive deficits and HRQL is unknown. OBJECTIVES: The objectives of this study were to (1) evaluate the relationship between HF severity, age, comorbidities, and cognitive deficits and HRQL among patients with chronic HF and (2) examine whether cognitive deficits mediated the relationship between HF severity and HRQL. DESIGN AND SAMPLE: This study was part of a larger explanatory study; 249 patients with HF completed face-to-face interviews. METHODS: Measures of HF severity, comorbidity (multiple comorbid conditions, hypertension, and depressive symptoms), cognitive function (domains of language, working memory, memory, psychomotor speed, and executive function), and HRQL were obtained. Clinical variables were abstracted from patients' records. Statistical analyses were conducted using descriptive statistics, Pearson correlation coefficients, and multiple linear regression analyses. RESULTS: Overall, the HRQL of patients was moderately poor. Heart failure severity, age, depressive symptoms, and total recall memory explained 55% of the variance in HRQL, but the contribution of memory was minimal (1%). Patients with more severe HF, younger age, and more depressive symptoms had poorer HRQL. Other cognitive function variables, multiple comorbidity, and hypertension were not significant explanatory variables for HRQL. Cognitive deficits did not mediate the relationship between HF severity and HRQL. CONCLUSIONS: Novel interventions targeted at improving HRQL continue to be urgently needed, particularly among younger patients and patients with depressive symptoms. Measures of HRQL are not sufficient as outcomes when investigating cognitive deficits in HF. Investigators need to include outcome measures of patients' actual abilities to perform daily activities and HF self-care.
BACKGROUND:Patients with chronic heart failure (HF) have cognitive deficits in memory, psychomotor speed, and executive function and poor health-related quality of life (HRQL), but the association between cognitive deficits and HRQL is unknown. OBJECTIVES: The objectives of this study were to (1) evaluate the relationship between HF severity, age, comorbidities, and cognitive deficits and HRQL among patients with chronic HF and (2) examine whether cognitive deficits mediated the relationship between HF severity and HRQL. DESIGN AND SAMPLE: This study was part of a larger explanatory study; 249 patients with HF completed face-to-face interviews. METHODS: Measures of HF severity, comorbidity (multiple comorbid conditions, hypertension, and depressive symptoms), cognitive function (domains of language, working memory, memory, psychomotor speed, and executive function), and HRQL were obtained. Clinical variables were abstracted from patients' records. Statistical analyses were conducted using descriptive statistics, Pearson correlation coefficients, and multiple linear regression analyses. RESULTS: Overall, the HRQL of patients was moderately poor. Heart failure severity, age, depressive symptoms, and total recall memory explained 55% of the variance in HRQL, but the contribution of memory was minimal (1%). Patients with more severe HF, younger age, and more depressive symptoms had poorer HRQL. Other cognitive function variables, multiple comorbidity, and hypertension were not significant explanatory variables for HRQL. Cognitive deficits did not mediate the relationship between HF severity and HRQL. CONCLUSIONS: Novel interventions targeted at improving HRQL continue to be urgently needed, particularly among younger patients and patients with depressive symptoms. Measures of HRQL are not sufficient as outcomes when investigating cognitive deficits in HF. Investigators need to include outcome measures of patients' actual abilities to perform daily activities and HF self-care.
Authors: Raymond L C Vogels; Philip Scheltens; Jutta M Schroeder-Tanka; Henry C Weinstein Journal: Eur J Heart Fail Date: 2006-12-14 Impact factor: 15.534
Authors: Donald Lloyd-Jones; Robert Adams; Mercedes Carnethon; Giovanni De Simone; T Bruce Ferguson; Katherine Flegal; Earl Ford; Karen Furie; Alan Go; Kurt Greenlund; Nancy Haase; Susan Hailpern; Michael Ho; Virginia Howard; Brett Kissela; Steven Kittner; Daniel Lackland; Lynda Lisabeth; Ariane Marelli; Mary McDermott; James Meigs; Dariush Mozaffarian; Graham Nichol; Christopher O'Donnell; Veronique Roger; Wayne Rosamond; Ralph Sacco; Paul Sorlie; Randall Stafford; Julia Steinberger; Thomas Thom; Sylvia Wasserthiel-Smoller; Nathan Wong; Judith Wylie-Rosett; Yuling Hong Journal: Circulation Date: 2008-12-15 Impact factor: 29.690
Authors: Mary Jane Sauvé; William R Lewis; Miriam Blankenbiller; Barbara Rickabaugh; Susan J Pressler Journal: J Card Fail Date: 2008-10-04 Impact factor: 5.712
Authors: David B Bekelman; John S Rumsfeld; Edward P Havranek; Traci E Yamashita; Evelyn Hutt; Sheldon H Gottlieb; Sydney M Dy; Jean S Kutner Journal: J Gen Intern Med Date: 2009-03-14 Impact factor: 5.128
Authors: Rajesh Kumar; Mary A Woo; Bramley V X Birrer; Paul M Macey; Gregg C Fonarow; Michele A Hamilton; Ronald M Harper Journal: Neurobiol Dis Date: 2008-10-31 Impact factor: 5.996
Authors: Vladimir Hachinski; Costantino Iadecola; Ron C Petersen; Monique M Breteler; David L Nyenhuis; Sandra E Black; William J Powers; Charles DeCarli; Jose G Merino; Raj N Kalaria; Harry V Vinters; David M Holtzman; Gary A Rosenberg; Anders Wallin; Martin Dichgans; John R Marler; Gabrielle G Leblanc Journal: Stroke Date: 2006-08-17 Impact factor: 7.914
Authors: Susan J Pressler; Alison Martineau; Judith Grossi; Bruno Giordani; Todd M Koelling; David L Ronis; Penny L Riley; Cheng-Chen Chou; Barbara J Sullivan; Dean G Smith Journal: Heart Lung Date: 2013-07-01 Impact factor: 2.210
Authors: Michael L Alosco; Mary Beth Spitznagel; Ronald Cohen; Lawrence H Sweet; Scott M Hayes; Richard Josephson; Joel Hughes; John Gunstad Journal: J Card Fail Date: 2015-01-05 Impact factor: 5.712
Authors: Michael L Alosco; Mary Beth Spitznagel; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Manfred van Dulmen; Joel Hughes; Jim Rosneck; John Gunstad Journal: J Clin Nurs Date: 2013-05-08 Impact factor: 3.036
Authors: Rebecca L Dekker; Terry A Lennie; Nancy M Albert; Mary K Rayens; Misook L Chung; Jia-Rong Wu; Eun Kyeung Song; Debra K Moser Journal: J Card Fail Date: 2011-09 Impact factor: 5.712
Authors: Jordan M Harrison; Matthew A Davis; Debra L Barton; Nancy K Janz; Susan J Pressler; Christopher R Friese Journal: Support Care Cancer Date: 2017-03-08 Impact factor: 3.603
Authors: Debra K Moser; Cynthia Arslanian-Engoren; Martha J Biddle; Misook Lee Chung; Rebecca L Dekker; Muna H Hammash; Gia Mudd-Martin; Abdullah S Alhurani; Terry A Lennie Journal: Curr Cardiol Rep Date: 2016-12 Impact factor: 2.931
Authors: Michael L Alosco; Mary Beth Spitznagel; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Donna Waechter; Joel Hughes; Jim Rosneck; John Gunstad Journal: Aging Clin Exp Res Date: 2011-12-19 Impact factor: 3.636