PURPOSE: To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS: One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 x 128 scan by SD-OCT were performed. RESULTS: The mean age was 55.6 +/- 16.4 years (range, 17-83), average refractive error was -2.17 +/- 4.82 (range, -23.50-3.75), and average axial length was 24.73 +/- 1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively). CONCLUSIONS: In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.
PURPOSE: To assess the relationship between macular retinal thickness and volume and age, sex, and refractive error/axial length with spectral domain-optical coherence tomography (SD-OCT). METHODS: One randomly selected eye of 198 consecutive ophthalmically normal subjects (104 men, 94 women) between July 2008 and January 2009, with corrected visual acuities better than 20/30 were included in this cross-sectional study. Complete ophthalmic examination, axial length measurement with a laser interferometer, and macular cube 512 x 128 scan by SD-OCT were performed. RESULTS: The mean age was 55.6 +/- 16.4 years (range, 17-83), average refractive error was -2.17 +/- 4.82 (range, -23.50-3.75), and average axial length was 24.73 +/- 1.98 mm (range, 21.52-32.51). The central subfield thickness, average inner macular thickness, and overall macular volume were significantly lower in the female subjects (partial correlation: P = 0.009, P = 0.027, and P = 0.042, respectively). As age increased, average inner macular thickness, average outer macular thickness, overall average macular thickness, and macular volume decreased significantly (partial correlation: P = 0.002, P = 0.002, P = 0.002, and P = 0.000, respectively). Refractive error had no significant influence in partial correlation analysis. Axial length correlated negatively with average outer macular thickness, overall average macular thickness, and macular volume (partial correlation: P = 0.006, P = 0.044, and P = 0.003, respectively). CONCLUSIONS: In normal subjects, SD-OCT showed that retinal thickness is related to age, sex, and axial length, with regional variations.
Authors: Nazli Demirkaya; Hille W van Dijk; Sanne M van Schuppen; Michael D Abràmoff; Mona K Garvin; Milan Sonka; Reinier O Schlingemann; Frank D Verbraak Journal: Invest Ophthalmol Vis Sci Date: 2013-07-22 Impact factor: 4.799
Authors: Alexander Pinhas; Moataz Razeen; Michael Dubow; Alexander Gan; Toco Y Chui; Nishit Shah; Mitul Mehta; Ronald C Gentile; Rishard Weitz; Joseph B Walsh; Yusufu N Sulai; Joseph Carroll; Alfredo Dubra; Richard B Rosen Journal: Invest Ophthalmol Vis Sci Date: 2014-11-20 Impact factor: 4.799