| Literature DB >> 20356104 |
Christoph J Rohbogner1, Stefan Wirth, Paul Knochel.
Abstract
The strong directing ability of the N,N,N',N'-tetramethyldiaminophosphorodiamidate group has been used to achieve selective metalations on various heterocycles such as pyridines, quinolines and quinoxalines with TMP-derived bases like TMPMgCl x LiCl, TMP(2)Mg x 2 LiCl, and TMP(2)Zn x 2 MgCl(2) x 2 LiCl. This protocol was applied in the synthesis of etoricoxib, talnetant and a P-selectin inhibitor.Entities:
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Year: 2010 PMID： 20356104 DOI： 10.1021/ol100453x
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005