BACKGROUND: Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated. AIM: To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria. MATERIAL AND METHODS: We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively. RESULTS: Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007). CONCLUSIONS: Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.
BACKGROUND:Microalbuminuria in Type 2 diabetes is associated with arterial endothelial dysfunction, but the venous bed was never evaluated. AIM: To study the endothelial function in the venous and arterial bed in patients with Type 2 diabetes with normoalbuminuria or microalbuminuria. MATERIAL AND METHODS: We evaluated 28 patients with Type 2 diabetes, glycated hemoglobin (HbA(₁c)) <7.5%, who were classified as normo- (albuminuria <30 mg/24 h; no.=16) or microalbuminuric (albuminuria 30-300 mg/24 h; no.=12). Venous and arterial endothelial function were assessed by the dorsal hand vein technique (venodilation by acetylcholine) and brachial artery flow-mediated vasodilation, respectively. RESULTS:Patients were normotensive (systolic arterial pressure: 131.1±10.6 mmHg) and on good metabolic control (HbA(₁c): 6.6±0.6%). Microalbuminuric patients presented impaired venous (32.9±17.4 vs 59.3±26.5%; p=0.004) and arterial vasodilation (1.8±0.9 vs 5.1±2.4; p<0.001), as compared to normoalbuminuric patients. There was a negative correlation between acetylcholine-induced venodilation and albuminuria (r=-0.62; p<0.001) and HbA(₁c) (r=-0.41; p=0.032). The same was observed between flow mediated arterial vasodilation and albuminuria (r=-0.49; p=0.007) and HbA(₁c) (r=-0.44; p=0.019). Venous and arterial vasodilation was positively correlated (r=0.50; p=0.007). CONCLUSIONS: Both venous and arterial endothelial function are impaired in Type 2 microalbuminuric diabetics, in spite of good metabolic control, suggesting that other factors are involved in its pathogenesis.
Authors: H Makino; S Okada; A Nagumo; T Sugisawa; Y Miyamoto; I Kishimoto; A Kikuchi-Taura; T Soma; A Taguchi; Y Yoshimasa Journal: Diabet Med Date: 2009-02 Impact factor: 4.359
Authors: U M Vischer; J J Emeis; H J Bilo; C D Stehouwer; C Thomsen; O Rasmussen; K Hermansen; C B Wollheim; J Ingerslev Journal: Thromb Haemost Date: 1998-12 Impact factor: 5.249
Authors: Georgios I Papaioannou; Richard L Seip; Neil J Grey; Deborah Katten; Amy Taylor; Silvio E Inzucchi; Lawrence H Young; Deborah A Chyun; Janice A Davey; Frans J Th Wackers; Ami E Iskandrian; Robert E Ratner; Evelyn C Robinson; Stella Carolan; Samuel Engel; Gary V Heller Journal: Am J Cardiol Date: 2004-08-01 Impact factor: 2.778
Authors: A M V Silva; L U Signori; R D M Plentz; H Moreno; E Barros; A Belló-Klein; B D Schaan; M C Irigoyen Journal: Braz J Med Biol Res Date: 2008-06 Impact factor: 2.590
Authors: Marcello C Bertoluci; Gislaine V Cé; Antônio Mv da Silva; Marco V Wainstein; Winston Boff; Marcia Puñales Journal: World J Diabetes Date: 2015-06-10
Authors: John P Forman; Lieneke Scheven; Paul E de Jong; Stephan J L Bakker; Gary C Curhan; Ron T Gansevoort Journal: Circulation Date: 2012-06-18 Impact factor: 29.690
Authors: Erhan Tenekecioglu; Mustafa Yilmaz; Osman Can Yontar; Kemal Karaagac; Fahriye Vatansever Agca; Ahmet Tutuncu; Mustafa Kuzeytemiz; Adem Bekler; Muhammed Senturk; Ufuk Aydin; Serafettin Demir Journal: Int J Clin Exp Med Date: 2014-10-15
Authors: Orlando M Gutiérrez; Yulia A Khodneva; Paul Muntner; Dana V Rizk; William M McClellan; Mary Cushman; David G Warnock; Monika M Safford Journal: JAMA Date: 2013-08-21 Impact factor: 56.272