| Literature DB >> 203535 |
Abstract
Phytohemagglutinin treatment of peripheral blood leukocytes from dengue nonimmune monkeys enhanced dengue-2 virus replication. Enhancement was due primarily to an increase in the number of infected cells. Destruction of mononuclear phagocytes with silica did not significantly inhibit virus replication in phytohemagglutinin-treated cultures. Pokeweed mitogen, concanavalin A, and streptolysin O stimulated increased deoxyribonucleic acid synthesis in monkey leukocytes but did not enhance virus replication. None of the mitogens significantly affected virus replication in cultures of dengue-immune monkey peripheral blood leukocytes.Entities:
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Year: 1978 PMID: 203535 PMCID: PMC414045 DOI: 10.1128/iai.19.1.40-45.1978
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441