Carmela M Reichel1, Ronald E See. 1. Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
Abstract
RATIONALE: Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention. MATERIALS AND METHODS: We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking. RESULTS: Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone. DISCUSSION: These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.
RATIONALE: Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention. MATERIALS AND METHODS: We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking. RESULTS:Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone. DISCUSSION: These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.
Authors: T E Scammell; I V Estabrooke; M T McCarthy; R M Chemelli; M Yanagisawa; M S Miller; C B Saper Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167
Authors: Brendan J Tunstall; Chelsea P Ho; Jianjing Cao; Janaína C M Vendruscolo; Brooke E Schmeichel; Rachel D Slack; Gianluigi Tanda; Alexandra J Gadiano; Rana Rais; Barbara S Slusher; George F Koob; Amy H Newman; Leandro F Vendruscolo Journal: Neuropharmacology Date: 2017-12-05 Impact factor: 5.250