OBJECTIVE: Telomeres shorten and aggregate with cellular senescence and oxidative stress. Telomerase and its catalytic component human telomerase reverse-transcriptase regulate telomere length. The pathogenesis of preeclampsia and intrauterine growth restriction involves hypoxic stress. We aimed to assess telomere length in trophoblasts from pregnancies with those complications. STUDY DESIGN: Placental specimens from 4 groups of patients were studied: severe preeclampsia, intrauterine growth restriction, preeclampsia combined with intrauterine growth restriction, and uncomplicated (control). Telomere length and human telomerase reverse-transcriptase expression were assessed by using quantitative fluorescence-in-situ protocol and immunohistochemistry. RESULTS: Telomere length was significantly lower in preeclampsia, intrauterine growth restriction, and preeclampsia plus intrauterine growth restriction placentas. More aggregates were found in preeclampsia, but not in intrauterine growth restriction placentas. Human telomerase reverse-transcriptase was significantly higher in the controls compared with the other groups. CONCLUSION: Telomeres are shorter in placentas from preeclampsia and intrauterine growth restriction pregnancies. Increased telomere aggregate formation in preeclampsia but not in intrauterine growth restriction pregnancies, implies different placental stress-related mechanisms in preeclampsia with or without intrauterine growth restriction. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: Telomeres shorten and aggregate with cellular senescence and oxidative stress. Telomerase and its catalytic component humantelomerase reverse-transcriptase regulate telomere length. The pathogenesis of preeclampsia and intrauterine growth restriction involves hypoxic stress. We aimed to assess telomere length in trophoblasts from pregnancies with those complications. STUDY DESIGN: Placental specimens from 4 groups of patients were studied: severe preeclampsia, intrauterine growth restriction, preeclampsia combined with intrauterine growth restriction, and uncomplicated (control). Telomere length and humantelomerase reverse-transcriptase expression were assessed by using quantitative fluorescence-in-situ protocol and immunohistochemistry. RESULTS: Telomere length was significantly lower in preeclampsia, intrauterine growth restriction, and preeclampsia plus intrauterine growth restriction placentas. More aggregates were found in preeclampsia, but not in intrauterine growth restriction placentas. Humantelomerase reverse-transcriptase was significantly higher in the controls compared with the other groups. CONCLUSION: Telomeres are shorter in placentas from preeclampsia and intrauterine growth restriction pregnancies. Increased telomere aggregate formation in preeclampsia but not in intrauterine growth restriction pregnancies, implies different placental stress-related mechanisms in preeclampsia with or without intrauterine growth restriction. Copyright 2010 Mosby, Inc. All rights reserved.
Authors: A Sood; S Salih; D Roh; L Lacharme-Lora; M Parry; B Hardiman; R Keehan; R Grummer; E Winterhager; P J Gokhale; P W Andrews; C Abbott; K Forbes; M Westwood; J D Aplin; E Ingham; I Papageorgiou; M Berry; J Liu; A D Dick; R J Garland; N Williams; R Singh; A K Simon; M Lewis; J Ham; L Roger; D M Baird; L A Crompton; M A Caldwell; H Swalwell; M Birch-Machin; G Lopez-Castejon; A Randall; H Lin; M-S Suleiman; W H Evans; R Newson; C P Case Journal: Nat Nanotechnol Date: 2011-11-06 Impact factor: 39.213
Authors: Christopher W Jones; Kyle C Esteves; Sarah A O Gray; Tegan N Clarke; Keegan Callerame; Katherine P Theall; Stacy S Drury Journal: Psychoneuroendocrinology Date: 2019-03-22 Impact factor: 4.905
Authors: Keri Horan Kalmbach; Danielle Mota Fontes Antunes; Roberta Caetano Dracxler; Taylor Warner Knier; Michelle Louise Seth-Smith; Fang Wang; Lin Liu; David Lawrence Keefe Journal: Fertil Steril Date: 2013-01 Impact factor: 7.329
Authors: Autumn J Broady; Matthew H Loichinger; Hyeong Jun Ahn; Philip M C Davy; Richard C Allsopp; Gillian D Bryant-Greenwood Journal: Placenta Date: 2016-12-18 Impact factor: 3.481
Authors: Christopher W Jones; Cecilia Gambala; Kyle C Esteves; Maeve Wallace; Reid Schlesinger; Marguerite O'Quinn; Laura Kidd; Katherine P Theall; Stacy S Drury Journal: Am J Obstet Gynecol Date: 2016-11-16 Impact factor: 8.661
Authors: Tsegaselassie Workalemahu; Daniel A Enquobahrie; Ermias Yohannes; Sixto E Sanchez; Bizu Gelaye; Chunfang Qiu; Michelle A Williams Journal: J Matern Fetal Neonatal Med Date: 2015-11-26