Literature DB >> 203502

Thyrotropin receptors in adipose tissue, retro-orbital tissue and lymphocytes.

T F Davies, C S Teng, S M McLachlan, B R Smith, R Hall.   

Abstract

Thyrotropin (TSH) receptors on retro-orbital muscle and fat have been implicated in the pathogenesis of Graves' exophthalmos and it has been suggested that TSH has a direct effect on human fat metabolism. We have therefore investigated the interaction of biologically active 125I-labelled TSH with membranes prepared from human adipose, retro-orbital and thyroid tissue. Since lymphocytes contain receptors for several polypeptide hormones, TSH binding to lymphocyte membranes was also studied. We were unable to demonstrate TSH receptors in adult human adipose tissue, retro-orbital muscle and fat, or peripheral blood lymphocytes. In contrast, adult and neonatal guinea pig adipose tissue membranes showed similar TSH binding characteristics to guinea pig thyroid membranes.

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Year:  1978        PMID： 203502     DOI： 10.1016/0303-7207(78)90072-2

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  18 in total

Review 1.  Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease.

Authors:  M Ludgate; G Baker
Journal:  Clin Exp Immunol       Date:  2002-02       Impact factor: 4.330

Review 2.  The TSH receptor reveals itself.

Authors:  Terry Davies; Russell Marians; Rauf Latif
Journal:  J Clin Invest       Date:  2002-07       Impact factor: 14.808

3.  Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease.

Authors:  Terry J Smith; Dolly A Padovani-Claudio; Ying Lu; Nupur Raychaudhuri; Roshini Fernando; Stephen Atkins; Erin F Gillespie; Andrew G Gianoukakis; Barbra S Miller; Paul G Gauger; Gerard M Doherty; Raymond S Douglas
Journal:  J Clin Endocrinol Metab       Date:  2011-09-28       Impact factor: 5.958

Review 4.  Graves' ophthalmopathy.

Authors:  Rebecca S Bahn
Journal:  N Engl J Med       Date:  2010-02-25       Impact factor: 91.245

5.  Clinical applications of assays for thyrotropin-receptor antibodies in Graves' disease.

Authors:  J Ginsberg; C von Westarp
Journal:  CMAJ       Date:  1986-05-15       Impact factor: 8.262

Review 6.  Risk factors for development or deterioration of Graves' ophthalmopathy.

Authors:  Marius N Stan; Rebecca S Bahn
Journal:  Thyroid       Date:  2010-07       Impact factor: 6.568

7.  Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.

Authors:  Roshini Fernando; Stephen Atkins; Nupur Raychaudhuri; Ying Lu; Bin Li; Raymond S Douglas; Terry J Smith
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-19       Impact factor: 11.205

8.  Lack of evidence supporting the presence of mRNA for the thyrotropin receptor in extra-ocular muscle.

Authors:  R Paschke; R Elisei; G Vassart; M Ludgate
Journal:  J Endocrinol Invest       Date:  1993-05       Impact factor: 4.256

9.  Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease.

Authors:  Shanli Tsui; Vibha Naik; Neil Hoa; Catherine J Hwang; Nikoo F Afifiyan; Amiya Sinha Hikim; Andrew G Gianoukakis; Raymond S Douglas; Terry J Smith
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422

10.  Demonstration of thyrotropin binding sites in orbital connective tissue: possible role in the pathogenesis of thyroid-associated ophthalmopathy.

Authors:  P Perros; P Kendall-Taylor
Journal:  J Endocrinol Invest       Date:  1994-03       Impact factor: 4.256
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