Literature DB >> 20347958

Multinucleation of spermatozoa and spermatids in infertile men chronically exposed to carbofuran.

Guadalupe Gallegos-Avila1, Jesús Ancer-Rodríguez, Alberto Niderhauser-García, Marta Ortega-Martínez, Gilberto Jaramillo-Rangel.   

Abstract

OBJECTIVE: To report the findings encountered in semen samples coming from two infertile men chronically exposed to carbofuran.
METHODS: Semen samples were collected and analyzed as recommended by the World Health Organization. A morphological analysis was carried out by light microscopy.
RESULTS: Seminal analysis revealed in the first case a total concentration of 42 million spermatozoa/mL with 17% motility and 20% normal shape. The second patient presented a total concentration of 5 million spermatozoa/mL with 6% motility and 2% normal shape. The patients presented a similar percentage of binucleated spermatozoa (28 and 26%) and of multinucleated spermatids (10 and 6%).
CONCLUSION: To our knowledge, this is the first time that alterations in semen samples of men exposed to carbofuran are reported. More research in this area is needed to make conclusions on the subject.

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Year:  2010        PMID: 20347958     DOI: 10.1016/j.reprotox.2010.03.007

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN: 0890-6238            Impact factor:   3.143


  3 in total

Review 1.  Environmental and occupational pesticide exposure and human sperm parameters: a systematic review.

Authors:  Sheena E Martenies; Melissa J Perry
Journal:  Toxicology       Date:  2013-02-22       Impact factor: 4.221

2.  High-Content Image-Based Single-Cell Phenotypic Analysis for the Testicular Toxicity Prediction Induced by Bisphenol A and Its Analogs Bisphenol S, Bisphenol AF, and Tetrabromobisphenol A in a Three-Dimensional Testicular Cell Co-culture Model.

Authors:  Lei Yin; Jacob Steven Siracusa; Emily Measel; Xueling Guan; Clayton Edenfield; Shenxuan Liang; Xiaozhong Yu
Journal:  Toxicol Sci       Date:  2020-02-01       Impact factor: 4.849

Review 3.  Assessing the reproductive health of men with occupational exposures.

Authors:  Steven M Schrader; Katherine L Marlow
Journal:  Asian J Androl       Date:  2014 Jan-Feb       Impact factor: 3.285

  3 in total

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