| Literature DB >> 20347728 |
S L Gómez1, A M Monteiro, S R Rabbani, A C Bloise, S M Carneiro, S Alves, M Gidlund, D S P Abdalla, A M Figueiredo Neto.
Abstract
In this work we report on a study of the morphological changes of LDL induced in vitro by metallic ions (Cu(2+) and Fe(3+)). These modifications were characterized by transmission electron microscopy, nuclear magnetic resonance and the Z-scan technique. The degree of oxidative modification of LDL was determined by the TBARS and lipid hydroperoxides assays. It is shown that distinct pathways for modifying lipoproteins lead to different morphological transformations of the particles characterized by changes in size and/or shape of the resulting particles, and by the tendency to induce aggregation of the particles. There were no evidence of melting of particles promoted by oxidative processes with Cu and Fe. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20347728 DOI： 10.1016/j.chemphyslip.2010.03.008
Source DB: PubMed Journal: Chem Phys Lipids ISSN： 0009-3084 Impact factor: 3.329