| Literature DB >> 20347591 |
Matthew G LaPorte1, Tandy L Draper, Lori E Miller, Charles W Blackledge, Lara K Leister, Eugene Amparo, Alison R Hussey, Dorothy C Young, Srinivas K Chunduru, Christopher A Benetatos, Gerry Rhodes, Ariamala Gopalsamy, Torsten Herbertz, Christopher J Burns, Stephen M Condon.
Abstract
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12. 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20347591 DOI： 10.1016/j.bmcl.2010.03.002
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823