Literature DB >> 203475

The metabolism of methadone by cultured mammalian cells.

P C Will, W D Noteboom.   

Abstract

Rat hepatoma tissue culture cells and mouse leukemic cells were found to metabolize [1-3H] methadone to at least 2 unidentified radioactive compounds. These results suggest that cultured cells may be useful models for studying methadone metabolism by specific cell types.

Entities:  

Mesh：

Substances：

Year:  1978        PMID： 203475     DOI： 10.1007/bf01944687

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  [Methylation of methadone on nitrogen to a quaternary ammonium base].

Authors:  O SCHAUMANN
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1960

2.  Established kidney cell lines of normal adult bovine and ovine origin.

Authors:  S H MADIN; N B DARBY
Journal:  Proc Soc Exp Biol Med       Date:  1958-07

3.  Thin-layer chromatographic separation of methadone and its primary metabolite in the presence of other drugs in urine specimens.

Authors:  N C Jain; W J Leung; R D Budd; T C Sneath
Journal:  J Chromatogr       Date:  1975-01-14

4.  A superior counting solution for water-soluble tritiated compounds.

Authors:  G W Carter; K Van Dyke
Journal:  Clin Chem       Date:  1971-07       Impact factor: 8.327

5.  Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

Authors:  E B Thompson; G M Tomkins; J F Curran
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

6.  Urinary metabolites of dl-methadone in maintenance subjects.

Authors:  H R Sullivan; S L Due
Journal:  J Med Chem       Date:  1973-08       Impact factor: 7.446

7.  Chromatographic separation of methadone, some of its metabolites and congeners.

Authors:  A L Misra; N L Vadlamani; S J Mule
Journal:  J Chromatogr       Date:  1972-05-03

8.  Synthesis and identification of metabolites resulting from the biotransformation of DL-methadone in man and in the rat.

Authors:  A Pohland; H E Boaz; H R Sullivan
Journal:  J Med Chem       Date:  1971-03       Impact factor: 7.446

9.  Uptake and intracellular localization of morphine in lysosomes and cell sap of cultured fibroblasts.

Authors:  M Liesse; G Lhoest; A Trouet; P Tulkens
Journal:  Arch Int Physiol Biochim       Date:  1976

10.  Urinary excretion of methadone in man.

Authors:  R C Baselt; L J Casarett
Journal:  Clin Pharmacol Ther       Date:  1972 Jan-Feb       Impact factor: 6.875
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.