Chris Beltran1, Mihir Naik, Thomas E Merchant. 1. Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN 38120, USA. chris.beltran@stjude.org
Abstract
PURPOSE: Quantify the dosimetric effect of inter- and intrafractional motion on intensity-modulated radiation therapy (IMRT) and three-dimensional (3D) planning via changes in the generalized equivalent uniform dose (gEUD), predicted tumor control probability (TCP) and normal tissue complication probability (NTCP) for pediatric ependymoma. METHODS AND MATERIALS: Twenty patients treated between 1998 and 2002 with a 3D plan (CTV = 1 cm, PTV = 5 mm) were selected. Two IMRT plans were created for the 1 cm CTV (PTV = 5 mm and PTV = 0 mm), and a third IMRT plan for a 5 mm CTV (PTV = 0 mm). Direct simulation with inter- and intrafractional motion was performed for 3D and IMRT plans based on daily pre and post-treatment cone beam CT information obtained from 20 well-matched patients (age, supine/prone, use of GA) on a localization protocol. Calculated TCP, NTCP, Conformity Index (CI), and predictive IQ were compared. RESULTS: IMRT improved the calculated TCP by 2.8+/-2.8 vs. 3D (p<0.001). Inter- and intrafractional motion results in a TCP loss of 0.4+/-0.7 (p=0.02) and 0.0+/-0.1 (p=0.14) for the IMRT plan with PTV = 0 mm. Mean NTCP for 3D and IMRT with PTV = 5 mm, PTV = 0 mm, and CTV = 5 mm for the cochlea was: 66.6, 29.4, 8.7. Mean NTCP change due to motion was <5%. CI was 0.70+/-0.06 for IMRT and 0.5+/-0.10 for 3D. Predictive IQ was 10.0+/-10.3 points higher for IMRT vs. 3D. CONCLUSIONS: IMRT improves calculated TCP vs. 3D. Daily localization can allow for a safe reduction in the PTV margin, while maintaining target coverage; reducing the CTV margin can further reduce NTCP and may reduce future side-effects. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
PURPOSE: Quantify the dosimetric effect of inter- and intrafractional motion on intensity-modulated radiation therapy (IMRT) and three-dimensional (3D) planning via changes in the generalized equivalent uniform dose (gEUD), predicted tumor control probability (TCP) and normal tissue complication probability (NTCP) for pediatric ependymoma. METHODS AND MATERIALS: Twenty patients treated between 1998 and 2002 with a 3D plan (CTV = 1 cm, PTV = 5 mm) were selected. Two IMRT plans were created for the 1 cm CTV (PTV = 5 mm and PTV = 0 mm), and a third IMRT plan for a 5 mm CTV (PTV = 0 mm). Direct simulation with inter- and intrafractional motion was performed for 3D and IMRT plans based on daily pre and post-treatment cone beam CT information obtained from 20 well-matched patients (age, supine/prone, use of GA) on a localization protocol. Calculated TCP, NTCP, Conformity Index (CI), and predictive IQ were compared. RESULTS: IMRT improved the calculated TCP by 2.8+/-2.8 vs. 3D (p<0.001). Inter- and intrafractional motion results in a TCP loss of 0.4+/-0.7 (p=0.02) and 0.0+/-0.1 (p=0.14) for the IMRT plan with PTV = 0 mm. Mean NTCP for 3D and IMRT with PTV = 5 mm, PTV = 0 mm, and CTV = 5 mm for the cochlea was: 66.6, 29.4, 8.7. Mean NTCP change due to motion was <5%. CI was 0.70+/-0.06 for IMRT and 0.5+/-0.10 for 3D. Predictive IQ was 10.0+/-10.3 points higher for IMRT vs. 3D. CONCLUSIONS: IMRT improves calculated TCP vs. 3D. Daily localization can allow for a safe reduction in the PTV margin, while maintaining target coverage; reducing the CTV margin can further reduce NTCP and may reduce future side-effects. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Lisa Be Shields; James M Coons; Catherine Dedich; Maria Ragains; Kristi Scalf; Todd W Vitaz; Aaron C Spalding Journal: Radiat Oncol Date: 2013-12-02 Impact factor: 3.481