B Hottor1, P Bosio, J Waugh, P J Diggle, S Byrne, J Ahenkorah, C D Ockleford. 1. Laboratory for Developmental Cell Sciences, Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom.
Abstract
OBJECTIVE(S): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. STUDY DESIGN: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). RESULTS: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. CONCLUSION(S): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cells. (c) 2010 Elsevier Ltd. All rights reserved.
OBJECTIVE(S): To define composition of chorionic plate and test effects of pre-eclampsia on basal plate composition. STUDY DESIGN: Retrospective cohort study where distinct area fractions were measured in: healthy term chorionic plate (CP: n = 11), healthy placental basal plate (n = 11), mild pre-eclamptic basal plate (n = 10) and severe pre-eclamptic basal plate (n = 11). RESULTS: CP lining is partly endothelial. Mean anchoring villus (AV)/acellular (NS) basal plate area ratio decreased in pre-eclampsia (p = 0.048). There was a decreasing trend with increasing disease severity. Basal plate endothelial cell proportion was not significantly lower in severe pre-eclampsia than in healthy or mild pre-eclamptics. CONCLUSION(S): An inverse relationship between the proportions of fibrin and anchoring villi indicates that increased basal plate fibrin deposition and reduced basal plate materno-fetal anchoring area are part of pre-eclamptic disease progression. Endothelium lining intervillous surfaces may originate from circulating maternal endothelial progenitor cells. (c) 2010 Elsevier Ltd. All rights reserved.
Authors: Fahrettin Kılıç; Yasemin Kayadibi; Mehmet Aytaç Yüksel; İbrahim Adaletli; Fethi Emre Ustabaşıoğlu; Mahmut Öncül; Rıza Madazlı; Mehmet Halit Yılmaz; İsmail Mihmanlı; Fatih Kantarcı Journal: Diagn Interv Radiol Date: 2015 May-Jun Impact factor: 2.630
Authors: Amy E Whitten; Roberto Romero; Steven J Korzeniewski; Adi L Tarca; Alyse G Schwartz; Lami Yeo; Zhong Dong; Sonia S Hassan; Tinnakorn Chaiworapongsa Journal: Am J Obstet Gynecol Date: 2013-01-17 Impact factor: 8.661