The effects of diabetes mellitus on wound healing.

Diabetes mellitus delays wound healing. Hyperglycemia leads to osmotic diuresis and subsequent decreased oxygenation and perfusion. It also limits PMN functioning and produces malnutrition by increasing hormones that cause catabolism. With meticulous monitoring of blood glucose levels and intensive insulin therapy of the postsurgical patients with diabetes, hyperglycemia can be reduced. If hyperglycemia is contained at a level less than 200 mg/dl, attention can be focused on supportive measures to promote wound healing.