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Literature DB >> 20346678

Polycomb group protein-mediated repression of transcription.

Abstract

The polycomb group (PcG) proteins are essential for the normal development of multicellular organisms. They form multi-protein complexes that work as transcriptional repressors of several thousand genes controlling differentiation pathways during development. How the PcG proteins work as transcriptional repressors is incompletely understood, but involves post-translational modifications of histones by two major PcG protein complexes: polycomb repressive complex 1 and polycomb repressive complex 2. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year: 2010 PMID： 20346678 DOI： 10.1016/j.tibs.2010.02.009

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

173 in total

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Review 5. Targeting epigenetic mechanisms in diabetic wound healing.

Authors: Aaron den Dekker; Frank M Davis; Steve L Kunkel; Katherine A Gallagher
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6. Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.

Authors: Gaylor Boulay; Marion Dubuissez; Capucine Van Rechem; Antoine Forget; Kristian Helin; Olivier Ayrault; Dominique Leprince
Journal: J Biol Chem Date: 2012-02-07 Impact factor: 5.157

Polycomb group protein-mediated repression of transcription.

Review 1. The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Review 2. Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways.

Review 3. Epigenetic mechanisms in inflammation.

4. SV40 transcription terminators stabilize the activity of regulatory elements in Drosophila melanogaster.

Review 5. Targeting epigenetic mechanisms in diabetic wound healing.

6. Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.

7. Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

8. Regulation of DU145 prostate cancer cell growth by Scm-like with four mbt domains 2.

9. STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

10. Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation.