| Literature DB >> 20346654 |
Guo-Xin Hu1, Guang Liang, Yanhui Chu, Xiaokun Li, Qing-Quang Lian, Han Lin, Yi He, Yadong Huang, Dianne O Hardy, Ren-Shan Ge.
Abstract
Non-steroidal compounds that inhibit 17beta-hydroxysteroid dehydrogenase isoform 3 (17beta-HSD3), an enzyme catalyzing the final step in testosterone biosynthesis in Leydig cells, are under development for male contraceptive or treatment of androgen dependent diseases including prostate cancer. A series of curcumin analogues with more stable chemical structures were compared to curcumin as inhibitors of 17beta-HSD3 in rat intact Leydig cells as well as rat and human testis microsomes. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20346654 DOI： 10.1016/j.bmcl.2010.02.089
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823