Literature DB >> 20346635

The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats.

Martin Weber1, Wei-Li Chang, Michelle R Breier, Alex Yang, Mark J Millan, Neal R Swerdlow.   

Abstract

Dopamine agonists reduce prepulse inhibition (PPI) of startle in rats. While it is used to predict antipsychotic efficacy, the specific receptor subtypes mediating this effect of dopamine agonists remain unclear. We characterized the effects of sumanirole, a highly selective D2 agonist, on PPI in rats. Sumanirole decreased PPI at 60-120 ms prepulse intervals, and increased PPI at 10-20 ms intervals. PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI. 2010 Elsevier B.V. and ECNP. All rights reserved.

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Year:  2010        PMID： 20346635      PMCID： PMC2864324          DOI： 10.1016/j.euroneuro.2010.02.011

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  17 in total

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Authors:  Tomas de Paulis
Journal:  Curr Opin Investig Drugs       Date:  2003-01

2.  Heritable differences in the dopaminergic regulation of sensorimotor gating. II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition.

Authors:  Neal R Swerdlow; Jody M Shoemaker; Pamela P Auerbach; Leia Pitcher; Jana Goins; Amanda Platten
Journal:  Psychopharmacology (Berl)       Date:  2003-05-21       Impact factor: 4.530

3.  Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats.

Authors:  M G Wadenberg; T L Sills; P J Fletcher; S Kapur
Journal:  Biol Psychiatry       Date:  2000-04-01       Impact factor: 13.382

4.  Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.

Authors:  Mark J Millan; Lisa Maiofiss; Didier Cussac; Valérie Audinot; Jean-A Boutin; Adrian Newman-Tancredi
Journal:  J Pharmacol Exp Ther       Date:  2002-11       Impact factor: 4.030

5.  Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.

Authors:  R F Heier; L A Dolak; J N Duncan; D K Hyslop; M F Lipton; I J Martin; M A Mauragis; M F Piercey; N F Nichols; P J Schreur; M W Smith; M W Moon
Journal:  J Med Chem       Date:  1997-02-28       Impact factor: 7.446

6.  Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease.

Authors:  Robert B McCall; Keith J Lookingland; Paul J Bédard; Rita M Huff
Journal:  J Pharmacol Exp Ther       Date:  2005-06-24       Impact factor: 4.030

7.  S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.

Authors:  M J Millan; A Gobert; A Newman-Tancredi; F Lejeune; D Cussac; J M Rivet; V Audinot; T Dubuffet; G Lavielle
Journal:  J Pharmacol Exp Ther       Date:  2000-06       Impact factor: 4.030

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Authors:  Cindy Achat-Mendes; Donna M Platt; Amy H Newman; Roger D Spealman
Journal:  Psychopharmacology (Berl)       Date:  2009-06-10       Impact factor: 4.530

9.  Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists.

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10.  The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats.

Authors:  Mark J Millan; Laetitia Seguin; Alain Gobert; Didier Cussac; Mauricette Brocco
Journal:  Psychopharmacology (Berl)       Date:  2004-02-19       Impact factor: 4.530
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Authors:  Casey E O'Neill; McKenzie L LeTendre; Ryan K Bachtell
Journal:  Neuropsychopharmacology       Date:  2011-12-14       Impact factor: 7.853

2.  Moderate-level prenatal alcohol exposure enhances acoustic startle magnitude and disrupts prepulse inhibition in adult rhesus monkeys.

Authors:  Mary L Schneider; Julie A Larson; Craig W Rypstat; Leslie M Resch; Andrew Roberts; Colleen F Moore
Journal:  Alcohol Clin Exp Res       Date:  2013-06-13       Impact factor: 3.455

3.  Pharmacological modulation of lateral habenular dopamine D2 receptors alters the anxiogenic response to cocaine in a runway model of drug self-administration.

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Journal:  Behav Brain Res       Date:  2016-05-04       Impact factor: 3.332

4.  Disparate effects of pramipexole on locomotor activity and sensorimotor gating in Sprague-Dawley rats.

Authors:  Wei-li Chang; Michelle R Breier; Alex Yang; Neal R Swerdlow
Journal:  Pharmacol Biochem Behav       Date:  2011-06-12       Impact factor: 3.533

5.  Stereochemical and neuroanatomical selectivity of pramipexole effects on sensorimotor gating in rats.

Authors:  Wei-Li Chang; Martin Weber; Michelle R Breier; Richard L Saint Marie; Samantha R Hines; Neal R Swerdlow
Journal:  Brain Res       Date:  2011-12-13       Impact factor: 3.252

Review 6.  Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.

Authors:  Adrian Newman-Tancredi; Mark S Kleven
Journal:  Psychopharmacology (Berl)       Date:  2011-03-11       Impact factor: 4.530

7.  BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats.

Authors:  Martin Weber; Tiffany Wu; William J Meilandt; Sara L Dominguez; Hilda O Solanoy; Janice A Maloney; Hai Ngu; Miriam Baca; Chung Kung; Lisa Lima; Timothy K Earr; Daniel Fleck; Shannon D Shields; William F Forrest; Oded Foreman; Søren Warming; Ryan J Watts; Kimberly Scearce-Levie
Journal:  Sci Rep       Date:  2017-03-10       Impact factor: 4.379

8.  Implication of dopamine D3 receptor activation in the reversion of Parkinson's disease-related motivational deficits.

Authors:  S Carnicella; G Drui; S Boulet; C Carcenac; M Favier; T Duran; M Savasta
Journal:  Transl Psychiatry       Date:  2014-06-17       Impact factor: 6.222

9.  Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats.

Authors:  Agata Casado-Sainz; Frederik Gudmundsen; Simone L Baerentzen; Denise Lange; Annemette Ringsted; Isabel Martinez-Tejada; Siria Medina; Hedok Lee; Claus Svarer; Sune H Keller; Martin Schain; Celia Kjaerby; Patrick M Fisher; Paul Cumming; Mikael Palner
Journal:  Neuropsychopharmacology       Date:  2021-11-01       Impact factor: 7.853
  9 in total

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