PURPOSE: The purpose of this study was to combine gene expression profiles and clinical factors to provide a better prediction model of local control after chemoradiotherapy for advanced head and neck cancer. MATERIAL AND METHODS: Gene expression data were available for a series of 92 advanced stage head and neck cancer patients treated with primary chemoradiotherapy. The effect of the Chung high-risk and Slebos HPV expression profiles on local control was analyzed in a model with age at diagnosis, gender, tumor site, tumor volume, T-stage and N-stage and HPV profile status. RESULTS: Among 75 patients included in the study, the only factors significantly predicting local control were tumor site (oral cavity vs. Pharynx, hazard ratio 4.2 [95% CI 1.4-12.5]), Chung gene expression status (high vs. Low risk profile, hazard ratio 4.4 [95% CI 1.5-13.3]) and HPV profile (negative vs. Positive profile, hazard ratio 6.2 [95% CI 1.7-22.5]). CONCLUSIONS: Chung high-risk expression profile and a negative HPV expression profile were significantly associated with increased risk of local recurrence after chemoradiotherapy in advanced pharynx and oral cavity tumors, independent of clinical factors. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
PURPOSE: The purpose of this study was to combine gene expression profiles and clinical factors to provide a better prediction model of local control after chemoradiotherapy for advanced head and neck cancer. MATERIAL AND METHODS: Gene expression data were available for a series of 92 advanced stage head and neck cancerpatients treated with primary chemoradiotherapy. The effect of the Chung high-risk and Slebos HPV expression profiles on local control was analyzed in a model with age at diagnosis, gender, tumor site, tumor volume, T-stage and N-stage and HPV profile status. RESULTS: Among 75 patients included in the study, the only factors significantly predicting local control were tumor site (oral cavity vs. Pharynx, hazard ratio 4.2 [95% CI 1.4-12.5]), Chung gene expression status (high vs. Low risk profile, hazard ratio 4.4 [95% CI 1.5-13.3]) and HPV profile (negative vs. Positive profile, hazard ratio 6.2 [95% CI 1.7-22.5]). CONCLUSIONS: Chung high-risk expression profile and a negative HPV expression profile were significantly associated with increased risk of local recurrence after chemoradiotherapy in advanced pharynx and oral cavity tumors, independent of clinical factors. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Ryan M Murphy; Jason Tasoulas; Alessandro Porrello; Miranda B Carper; Yi-Hsuan Tsai; Alisha R Coffey; Sunil Kumar; Peter Yf Zeng; Travis P Schrank; Bentley R Midkiff; Stephanie Cohen; Ashley H Salazar; Michele C Hayward; D Neil Hayes; Andrew Olshan; Gaorav P Gupta; Anthony C Nichols; Wendell G Yarbrough; Chad V Pecot; Antonio L Amelio Journal: Cancer Res Commun Date: 2022-09-15
Authors: Jolien Heukelom; Olga Hamming; Harry Bartelink; Frank Hoebers; Jordi Giralt; Teresa Herlestam; Marcel Verheij; Michiel van den Brekel; Wouter Vogel; Nick Slevin; Eric Deutsch; Jan-Jakob Sonke; Philippe Lambin; Coen Rasch Journal: BMC Cancer Date: 2013-02-22 Impact factor: 4.430
Authors: Ji Hyun Chang; Won Il Jang; Yong Bae Kim; Jin Hee Kim; Young Seok Kim; Yeon Sil Kim; Won Park; Juree Kim; Won Sup Yoon; Joo-Young Kim; Hak Jae Kim Journal: J Gynecol Oncol Date: 2016-03 Impact factor: 4.401