Emma J Lawrence1, Philip K McGuire2, Matthew Allin2, Muriel Walshe2, Vincent Giampietro3, Robin M Murray2, Larry Rifkin2, Chiari Nosarti2. 1. Department of Psychiatry, Biomedical Research Centre for Mental Health, Institute of Psychiatry and King's College London, London, United Kingdom. Electronic address: e.lawrence@iop.kcl.ac.uk. 2. Department of Psychiatry, Biomedical Research Centre for Mental Health, Institute of Psychiatry and King's College London, London, United Kingdom. 3. Department of Biostatistics and Computing, Institute of Psychiatry and King's College London, London, United Kingdom.
Abstract
OBJECTIVE: To determine whether preterm birth influences functional neuronal development in adulthood. STUDY DESIGN: We evaluated adults born very preterm (VPT; < 33 weeks of gestation) using a verbal paired-associate learning task within a functional magnetic resonance imaging paradigm. Hippocampi and parahippocampal gyri gray matter volumes were also quantified. RESULTS: Despite similar task performance compared with control participants, VPT adults showed increased brain activation in the left parahippocampal and precentral gyri during Encoding, and in the precentral gyrus during Recall. Very preterm participants also had decreased gray matter volume in the left and right hippocampi yet increased gray matter in the left parahippocampal gyrus. In VPT participants alone, activation in the left parahippocampal gyrus during Encoding (VPT>control participants) was positively associated with gray matter volume in the left parahippocampal gyrus, with VPT participants with the youngest gestational age (eg, born 28 weeks or less) having both increased gray matter and functional activation in this region. These results may reflect the process of neural reorganization after early brain injury. CONCLUSION: Preterm birth leads to functional neuronal differences in adulthood, which are meditated by both structural variations in task-specific regions, and gestational age. Copyright 2010 Mosby, Inc. All rights reserved.
OBJECTIVE: To determine whether preterm birth influences functional neuronal development in adulthood. STUDY DESIGN: We evaluated adults born very preterm (VPT; < 33 weeks of gestation) using a verbal paired-associate learning task within a functional magnetic resonance imaging paradigm. Hippocampi and parahippocampal gyri gray matter volumes were also quantified. RESULTS: Despite similar task performance compared with control participants, VPT adults showed increased brain activation in the left parahippocampal and precentral gyri during Encoding, and in the precentral gyrus during Recall. Very preterm participants also had decreased gray matter volume in the left and right hippocampi yet increased gray matter in the left parahippocampal gyrus. In VPT participants alone, activation in the left parahippocampal gyrus during Encoding (VPT>control participants) was positively associated with gray matter volume in the left parahippocampal gyrus, with VPT participants with the youngest gestational age (eg, born 28 weeks or less) having both increased gray matter and functional activation in this region. These results may reflect the process of neural reorganization after early brain injury. CONCLUSION: Preterm birth leads to functional neuronal differences in adulthood, which are meditated by both structural variations in task-specific regions, and gestational age. Copyright 2010 Mosby, Inc. All rights reserved.
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