Literature DB >> 20345973

REVIEW: Apathy diagnosis, assessment, and treatment in Alzheimer's disease.

Philippe H Robert1, Emmanuel Mulin, Patrick Malléa, Renaud David.   

Abstract

Apathy is defined as a disorder of motivation. There is wide acknowledgement that apathy is an important behavioral syndrome in Alzheimer's disease and in various neuropsychiatric disorders. In light of recent research and the renewed interest in the correlates and impacts of apathy and in its treatments, it is important to develop criteria for apathy that will be widely accepted, have clear operational steps, and be easy to apply in clinical practice and in research settings. Meeting these needs was the focus for a task force that included members of the European Psychiatric Association, the European Alzheimer's Disease Consortium and experts from Europe, Australia and North America.
© 2010 Blackwell Publishing Ltd.

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Year:  2010        PMID: 20345973      PMCID: PMC6493869          DOI: 10.1111/j.1755-5949.2009.00132.x

Source DB:  PubMed          Journal:  CNS Neurosci Ther        ISSN: 1755-5930            Impact factor:   5.243


  71 in total

1.  Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimer's disease and nondemented patients.

Authors:  O Migneco; M Benoit; P M Koulibaly; I Dygai; C Bertogliati; P Desvignes; P H Robert; G Malandain; F Bussiere; J Darcourt
Journal:  Neuroimage       Date:  2001-05       Impact factor: 6.556

2.  Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.

Authors:  N D Volkow; J Logan; J S Fowler; G J Wang; R C Gur; C Wong; C Felder; S J Gatley; Y S Ding; R Hitzemann; N Pappas
Journal:  Am J Psychiatry       Date:  2000-01       Impact factor: 18.112

Review 3.  Negative symptoms: the 'pathology' of motivation and goal-directed behaviour.

Authors:  R G Brown; G Pluck
Journal:  Trends Neurosci       Date:  2000-09       Impact factor: 13.837

4.  Behavioral and psychological symptoms in Alzheimer's disease. Relation between apathy and regional cerebral perfusion.

Authors:  M Benoit; I Dygai; O Migneco; P H Robert; C Bertogliati; J Darcourt; J Benoliel; V Aubin-Brunet; D Pringuey
Journal:  Dement Geriatr Cogn Disord       Date:  1999 Nov-Dec       Impact factor: 2.959

5.  The occurrence of depressive symptoms in the preclinical phase of AD: a population-based study.

Authors:  A K Berger; L Fratiglioni; Y Forsell; B Winblad; L Bäckman
Journal:  Neurology       Date:  1999-12-10       Impact factor: 9.910

Review 6.  Cholinergic interneuron characteristics and nicotinic properties in the striatum.

Authors:  Fu-Ming Zhou; Charles J Wilson; John A Dani
Journal:  J Neurobiol       Date:  2002-12

7.  Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour.

Authors:  R D Rogers; A J Blackshaw; H C Middleton; K Matthews; K Hawtin; C Crowley; A Hopwood; C Wallace; J F Deakin; B J Sahakian; T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  1999-10       Impact factor: 4.530

8.  Serotonin-dopamine interactions in the control of conditioned reinforcement and motor behavior.

Authors:  D M Sasaki-Adams; A E Kelley
Journal:  Neuropsychopharmacology       Date:  2001-09       Impact factor: 7.853

9.  Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis.

Authors:  Michel Benoit; Pierre Malick Koulibaly; Octave Migneco; Jacques Darcourt; Dominique J Pringuey; Philippe H Robert
Journal:  Psychiatry Res       Date:  2002-06-15       Impact factor: 3.222

10.  Syndromic validity of apathy in Alzheimer's disease.

Authors:  S E Starkstein; G Petracca; E Chemerinski; J Kremer
Journal:  Am J Psychiatry       Date:  2001-06       Impact factor: 18.112

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  18 in total

1.  The Brazilian version of the Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity in dementia.

Authors:  Florindo Stella; Orestes Vicente Forlenza; Jerson Laks; Larissa Pires de Andrade; Michelle A Ljubetic Avendaño; Elisandra Villela Gasparetto Sé; João de Castilho Cação; Constantine G Lyketsos; Kate de Medeiros
Journal:  Int Psychogeriatr       Date:  2013-06-14       Impact factor: 3.878

2.  Relationship between apathy and tumor location, size, and brain edema in patients with intracranial meningioma.

Authors:  Yihua Peng; Chunhong Shao; Ye Gong; Xuehai Wu; Weijun Tang; Shenxun Shi
Journal:  Neuropsychiatr Dis Treat       Date:  2015-07-13       Impact factor: 2.570

Review 3.  Apathy in Alzheimer's disease: any effective treatment?

Authors:  Raffaele Rea; Anna Carotenuto; Angiola M Fasanaro; Enea Traini; Francesco Amenta
Journal:  ScientificWorldJournal       Date:  2014-02-02

Review 4.  Subtle neuropsychiatric symptoms of glioblastoma multiforme misdiagnosed as depression.

Authors:  Raphael Jerome Leo; Jill N Frodey; Matthew L Ruggieri
Journal:  BMJ Case Rep       Date:  2020-03-17

5.  "He Just Doesn't Want to Get Out of the Chair and Do It": The Impact of Apathy in People with Dementia on Their Carers.

Authors:  Chern Yi Marybeth Chang; Waqaar Baber; Tom Dening; Jennifer Yates
Journal:  Int J Environ Res Public Health       Date:  2021-06-11       Impact factor: 3.390

6.  Are Dementia Patient's Engagement Using Tailored Stimuli the Same? The Apathy Dilemma in Nursing Home Residents.

Authors:  Elsa Leone; Audrey Deudon; Julie Piano; Philippe Robert; Arnaud Dechamps
Journal:  Curr Gerontol Geriatr Res       Date:  2012-08-26

7.  Apathy and white matter integrity in Alzheimer's disease: a whole brain analysis with tract-based spatial statistics.

Authors:  Changtae Hahn; Hyun-Kook Lim; Wang Yeon Won; Kook Jin Ahn; Won-Sang Jung; Chang Uk Lee
Journal:  PLoS One       Date:  2013-01-03       Impact factor: 3.240

Review 8.  The translational study of apathy-an ecological approach.

Authors:  Flurin Cathomas; Matthias N Hartmann; Erich Seifritz; Christopher R Pryce; Stefan Kaiser
Journal:  Front Behav Neurosci       Date:  2015-09-09       Impact factor: 3.558

Review 9.  Characterization of reward and effort mechanisms in apathy.

Authors:  Valerie Bonnelle; Kai-Riin Veromann; Stephanie Burnett Heyes; Elena Lo Sterzo; Sanjay Manohar; Masud Husain
Journal:  J Physiol Paris       Date:  2014-04-18

Review 10.  "Is dopamine involved in Alzheimer's disease?".

Authors:  Alessandro Martorana; Giacomo Koch
Journal:  Front Aging Neurosci       Date:  2014-09-25       Impact factor: 5.750

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