Literature DB >> 20345417

Signalling and pharmacological properties of the P2Y receptor.

T K Harden1, J I Sesma, I P Fricks, E R Lazarowski.   

Abstract

The P2Y(14) receptor is a relatively broadly expressed G protein-coupled receptor that is prominently associated with immune and inflammatory cells as well as with many epithelia. This receptor historically was thought to be activated selectively by UDP-glucose and other UDP-sugars. However, UDP is also a very potent agonist of this receptor, and may prove to be one of its most important cognate activators.

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Year:  2010        PMID： 20345417      PMCID： PMC2913438          DOI： 10.1111/j.1748-1716.2010.02116.x

Source DB:  PubMed          Journal:  Acta Physiol (Oxf)        ISSN： 1748-1708            Impact factor:   6.311


  65 in total

Review 1.  Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.

Authors:  Eduardo R Lazarowski; Richard C Boucher; T Kendall Harden
Journal:  Mol Pharmacol       Date:  2003-10       Impact factor: 4.436

Review 2.  Regulation of platelet functions by P2 receptors.

Authors:  Christian Gachet
Journal:  Annu Rev Pharmacol Toxicol       Date:  2006       Impact factor: 13.820

3.  ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors.

Authors:  Yu Chen; Ross Corriden; Yoshiaki Inoue; Linda Yip; Naoyuki Hashiguchi; Annelies Zinkernagel; Victor Nizet; Paul A Insel; Wolfgang G Junger
Journal:  Science       Date:  2006-12-15       Impact factor: 47.728

4.  The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation.

Authors:  Vielska M Brautigam; George R Dubyak; Jessica M Crain; Jyoti J Watters
Journal:  Purinergic Signal       Date:  2008-02-08       Impact factor: 3.765

5.  Agonist action of adenosine triphosphates at the human P2Y1 receptor.

Authors:  R K Palmer; J L Boyer; J B Schachter; R A Nicholas; T K Harden
Journal:  Mol Pharmacol       Date:  1998-12       Impact factor: 4.436

Review 6.  P2X receptors as cell-surface ATP sensors in health and disease.

Authors:  Baljit S Khakh; R Alan North
Journal:  Nature       Date:  2006-08-03       Impact factor: 49.962

7.  Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.

Authors:  Yi Dai; Shenglan Wang; Makoto Tominaga; Satoshi Yamamoto; Tetsuo Fukuoka; Tomohiro Higashi; Kimiko Kobayashi; Koichi Obata; Hiroki Yamanaka; Koichi Noguchi
Journal:  J Clin Invest       Date:  2007-07       Impact factor: 14.808

8.  Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.

Authors:  Arijit Das; Hyojin Ko; Lauren E Burianek; Matthew O Barrett; T Kendall Harden; Kenneth A Jacobson
Journal:  J Med Chem       Date:  2010-01-14       Impact factor: 7.446

9.  GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.

Authors:  Darren J Moore; Paul R Murdock; Jeannette M Watson; Richard L M Faull; Henry J Waldvogel; Philip G Szekeres; Shelagh Wilson; Katie B Freeman; Piers C Emson
Journal:  Brain Res Mol Brain Res       Date:  2003-10-21

Review 10.  Control of epithelial transport via luminal P2 receptors.

Authors:  Jens Leipziger
Journal:  Am J Physiol Renal Physiol       Date:  2003-03
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  37 in total

1.  The impact of commercially available purinergic ligands on purinergic signalling research.

Authors:  J R Flanaghan; S J Roome
Journal:  Purinergic Signal       Date:  2011-10-27       Impact factor: 3.765

2.  Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells.

Authors:  Elizabeth A Mazzio; Nawal Boukli; Nery Rivera; Karam F A Soliman
Journal:  Cancer Sci       Date:  2012-02-14       Impact factor: 6.716

Review 3.  G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions.

Authors:  Kenneth A Jacobson; Ramachandran Balasubramanian; Francesca Deflorian; Zhan-Guo Gao
Journal:  Purinergic Signal       Date:  2012-02-29       Impact factor: 3.765

4.  Differential expression of genes related to purinergic signaling in smooth muscle cells, PDGFRα-positive cells, and interstitial cells of Cajal in the murine colon.

Authors:  L E Peri; K M Sanders; V N Mutafova-Yambolieva
Journal:  Neurogastroenterol Motil       Date:  2013-06-30       Impact factor: 3.598

5.  Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception.

Authors:  H O Vongtau; E G Lavoie; J Sévigny; D C Molliver
Journal:  Neuroscience       Date:  2011-07-27       Impact factor: 3.590

6.  Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.

Authors:  Tiina A Jokela; Riikka Kärnä; Katri M Makkonen; Jarmo T Laitinen; Raija H Tammi; Markku I Tammi
Journal:  J Biol Chem       Date:  2014-05-20       Impact factor: 5.157

Review 7.  Pharmacology of the new P2Y12 receptor inhibitors: insights on pharmacokinetic and pharmacodynamic properties.

Authors:  Nicola Ferri; Alberto Corsini; Stefano Bellosta
Journal:  Drugs       Date:  2013-10       Impact factor: 9.546

Review 8.  UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.

Authors:  Eduardo R Lazarowski; T Kendall Harden
Journal:  Mol Pharmacol       Date:  2015-03-31       Impact factor: 4.436

9.  Selective induction of P2Y14 receptor by RANKL promotes osteoclast formation.

Authors:  Seung Ah Lee; Jin Hee Park; Soo Young Lee
Journal:  Mol Cells       Date:  2013-09-17       Impact factor: 5.034

10.  A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Authors:  Matthew O Barrett; Juliana I Sesma; Christopher B Ball; P Suresh Jayasekara; Kenneth A Jacobson; Eduardo R Lazarowski; T Kendall Harden
Journal:  Mol Pharmacol       Date:  2013-04-16       Impact factor: 4.436
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