Literature DB >> 20345141

Chemoenzymatic synthesis of rivastigmine via dynamic kinetic resolution as a key step.

Kiwon Han1, Cheolwoo Kim, Jaiwook Park, Mahn-Joo Kim.   

Abstract

A practical and efficient procedure for the synthesis of rivastigmine was developed. This procedure includes dynamic kinetic resolution using a polymer-bound ruthenium complex and a lipase in combination as a key step. Enantiopure (-)-rivastigmine was obtained from commercially available 3'-hydroxyacetophenone via five steps in overall 57% yield.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20345141     DOI： 10.1021/jo9027374

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.

Authors:  Oscar Verho; Jan-E Bäckvall
Journal:  J Am Chem Soc       Date:  2015-03-19       Impact factor: 15.419

2.  Direct Asymmetric Reductive Amination for the Synthesis of (S)-Rivastigmine.

Authors:  Guorui Gao; Shaozhi Du; Yang Yang; Xue Lei; Haizhou Huang; Mingxin Chang
Journal:  Molecules       Date:  2018-08-31       Impact factor: 4.411
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.