Literature DB >> 20345132

Functional hyperbranched polymers: toward targeted in vivo 19F magnetic resonance imaging using designed macromolecules.

Kristofer J Thurecht1, Idriss Blakey, Hui Peng, Oliver Squires, Steven Hsu, Cameron Alexander, Andrew K Whittaker.   

Abstract

We have demonstrated the design and synthesis of hyperbranched molecules that can be successfully imaged in vivo using (19)F MRI in under 10 min. These polymers are cytocompatible following chain extension with PEGMA. In addition, functionalization of these macromolecules can be achieved in a facile manner and with accessible and correct ligand presentation. Such hyperbranched polymers hold promise as new generation tracking and targeting MRI contrast agents.

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Year:  2010        PMID: 20345132     DOI: 10.1021/ja100252y

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN: 0002-7863            Impact factor:   15.419


  22 in total

1.  Fluorinated paramagnetic chelates as potential multi-chromic 19F tracer agents.

Authors:  Zhong-Xing Jiang; Yue Feng; Yihua Bruce Yu
Journal:  Chem Commun (Camb)       Date:  2011-05-26       Impact factor: 6.222

Review 2.  Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.

Authors:  Daniel Bobo; Kye J Robinson; Jiaul Islam; Kristofer J Thurecht; Simon R Corrie
Journal:  Pharm Res       Date:  2016-06-14       Impact factor: 4.200

3.  Base-catalyzed diastereoselective trimerization of trifluoroacetone.

Authors:  Anthony P Silvestri; Philip E Dawson
Journal:  Org Biomol Chem       Date:  2017-06-08       Impact factor: 3.876

4.  Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen Receptor·Coactivator Protein-Protein Interaction by 19F NMR.

Authors:  Caitlin M Tressler; Neal J Zondlo
Journal:  Biochemistry       Date:  2017-02-15       Impact factor: 3.162

5.  Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles.

Authors:  Jaqueline D Wallat; Anna E Czapar; Charlie Wang; Amy M Wen; Kristen S Wek; Xin Yu; Nicole F Steinmetz; Jonathan K Pokorski
Journal:  Biomacromolecules       Date:  2016-12-19       Impact factor: 6.988

6.  Azide-Terminated RAFT Polymers for Biological Applications.

Authors:  Ziwen Jiang; Huan He; Hongxu Liu; S Thayumanavan
Journal:  Curr Protoc Chem Biol       Date:  2020-12

7.  Target binding improves relaxivity in aptamer-gadolinium conjugates.

Authors:  Elyse D Bernard; Michael A Beking; Karunanithi Rajamanickam; Eve C Tsai; Maria C Derosa
Journal:  J Biol Inorg Chem       Date:  2012-08-19       Impact factor: 3.358

8.  Ultrahigh (19)F Loaded Cu1.75S Nanoprobes for Simultaneous (19)F Magnetic Resonance Imaging and Photothermal Therapy.

Authors:  Hongli Chen; Manli Song; Juan Tang; Gaofei Hu; Suying Xu; Zhide Guo; Nannan Li; Jiabin Cui; Xianzhong Zhang; Xiaoyuan Chen; Leyu Wang
Journal:  ACS Nano       Date:  2016-01-12       Impact factor: 15.881

9.  Using fluorine-containing amphiphilic random copolymers to manipulate the quantum yields of aggregation-induced emission fluorophores in aqueous solutions and the use of these polymers for fluorescent bioimaging.

Authors:  Hongguang Lu; Fengyu Su; Qian Mei; Yanqing Tian; Wenjing Tian; Roger H Johnson; Deirdre R Meldrum
Journal:  J Mater Chem       Date:  2012-03-14

10.  Fluorinated polyurethane scaffolds for 19F magnetic resonance imaging.

Authors:  Twan Lammers; Marianne E Mertens; Philipp Schuster; Khosrow Rahimi; Yang Shi; Volkmar Schulz; Alexander J C Kuehne; Stefan Jockenhoevel; Fabian Kiessling
Journal:  Chem Mater       Date:  2017-04-11       Impact factor: 9.811

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