Literature DB >> 20339400

Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.

Hideki Hashizume1, Hayamitsu Adachi, Masayuki Igarashi, Yoshio Nishimura, Yuzuru Akamatsu.   

Abstract

The time-kill studies using pargamicin A against Staphylococcus aureus and Enterococcus faecalis were performed. The effects of the incorporation of radioactive precursors into macromolecules, membrane potential and function using fluorescent dyes were also examined. These studies revealed that rapid bactericidal activity of pargamicin A correlates with the perturbation of bacterial cell membrane potential and membrane function.

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Year:  2010        PMID： 20339400     DOI： 10.1038/ja.2010.29

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Valgamicin C, a novel cyclic depsipeptide containing the unusual amino acid cleonine, and related valgamicins A, T and V produced by Amycolatopsis sp. ML1-hF4.

Authors:  Hideki Hashizume; Kiyoko Iijima; Kazuma Yamashita; Tomoyuki Kimura; Shun-Ichi Wada; Ryuichi Sawa; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2017-11-15       Impact factor: 2.649

2.  Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate.

Authors:  Hideki Hashizume; Ryuichi Sawa; Shigeko Harada; Masayuki Igarashi; Hayamitsu Adachi; Yoshio Nishimura; Akio Nomoto
Journal:  Antimicrob Agents Chemother       Date:  2011-05-31       Impact factor: 5.191

3.  Interactions of disulfide-constrained cyclic tetrapeptides with Cu(2+).

Authors:  Liyun Zhang; Zhaofeng Luo; Lidong Zhang; Liangyuan Jia; Lifang Wu
Journal:  J Biol Inorg Chem       Date:  2013-01-23       Impact factor: 3.358

Review 4.  Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis.

Authors:  Zhiqiang Song; Tangchang Xu; Junfei Wang; Yage Hou; Chuansheng Liu; Sisi Liu; Shaohua Wu
Journal:  Molecules       Date:  2021-03-26       Impact factor: 4.411
  4 in total

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