Literature DB >> 20338639

Transformation of dendritic cells from plasmacytoid to myeloid in a leukemic plasmacytoid dendritic cell line (PMDC05).

Norihiro Watanabe1, Miwako Narita, Akie Yamahira, Takeshi Nakamura, Nozomi Tochiki, Anri Saitoh, Masami Kaji, Shigeo Hashimoto, Tatsuo Furukawa, Ken Toba, Ichiro Fuse, Yoshifusa Aizawa, Masuhiro Takahashi.   

Abstract

We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1(-)CD123(+) cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1(-)CD123(+) cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1(+)CD123(-) cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20338639     DOI： 10.1016/j.leukres.2010.03.002

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  6 in total

Review 1.  Airway Macrophage and Dendritic Cell Subsets in the Resting Human Lung.

Authors:  Vineet Indrajit Patel; Jordan Patrick Metcalf
Journal:  Crit Rev Immunol       Date:  2018       Impact factor: 2.214

2.  The stimulatory effect of fusobacteria on dendritic cells under aerobic or anaerobic conditions.

Authors:  Shigeo Koido; Sankichi Horiuchi; Shin Kan; Tsuuse Bito; Zensho Ito; Kan Uchiyama; Masayuki Saruta; Nobuhiro Sato; Toshifumi Ohkusa
Journal:  Sci Rep       Date:  2022-06-23       Impact factor: 4.996

Review 3.  Neoplasms derived from plasmacytoid dendritic cells.

Authors:  Fabio Facchetti; Marta Cigognetti; Simona Fisogni; Giuseppe Rossi; Silvia Lonardi; William Vermi
Journal:  Mod Pathol       Date:  2016-01-08       Impact factor: 7.842

4.  Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene.

Authors:  Minami Iwabuchi; Miwako Narita; Takayoshi Uchiyama; Shunpei Iwaya; Eri Oiwa; Yoshinori Nishizawa; Shigeo Hashimoto; Aude Bonehill; Noriyuki Kasahara; Jun Takizawa; Masuhiro Takahashi
Journal:  Mol Med Rep       Date:  2015-04-24       Impact factor: 2.952

5.  Characterization of CD56+ dendritic-like cells: a normal counterpart of blastic plasmacytoid dendritic cell neoplasm?

Authors:  Yohei Osaki; Akihiko Yokohama; Akio Saito; Kenichi Tahara; Kunio Yanagisawa; Yoshiyuki Ogawa; Takuma Ishizaki; Takeki Mitsui; Hiromi Koiso; Makiko Takizawa; Hideki Uchiumi; Takayuki Saitoh; Hiroshi Handa; Hirokazu Murakami; Norifumi Tsukamoto; Yoshihisa Nojima
Journal:  PLoS One       Date:  2013-11-29       Impact factor: 3.240

6.  Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.

Authors:  David Olagnier; Aske M Brandtoft; Camilla Gunderstofte; Nikolaj L Villadsen; Christian Krapp; Anne L Thielke; Anders Laustsen; Suraj Peri; Anne Louise Hansen; Lene Bonefeld; Jacob Thyrsted; Victor Bruun; Marie B Iversen; Lin Lin; Virginia M Artegoitia; Chenhe Su; Long Yang; Rongtuan Lin; Siddharth Balachandran; Yonglun Luo; Mette Nyegaard; Bernadette Marrero; Raphaela Goldbach-Mansky; Mona Motwani; Dylan G Ryan; Katherine A Fitzgerald; Luke A O'Neill; Anne K Hollensen; Christian K Damgaard; Frank V de Paoli; Hanne C Bertram; Martin R Jakobsen; Thomas B Poulsen; Christian K Holm
Journal:  Nat Commun       Date:  2018-08-29       Impact factor: 14.919
  6 in total

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