Estil Y Strawn1, David Bick, Amy Swanson. 1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. rwutsche@mcw.edu
Abstract
OBJECTIVE: To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility. DESIGN: Case report. SETTING: Academic medical center. PATIENT(S): Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient. INTERVENTION(S): Assisted reproductive technology. MAIN OUTCOME MEASURE(S): Neonatal and pediatric morphologic evaluation by geneticists. RESULT(S): Two children with the morphologic features consistent with the criteria for the diagnosis of BWS. CONCLUSION(S): Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility. DESIGN: Case report. SETTING: Academic medical center. PATIENT(S): Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient. INTERVENTION(S): Assisted reproductive technology. MAIN OUTCOME MEASURE(S): Neonatal and pediatric morphologic evaluation by geneticists. RESULT(S): Two children with the morphologic features consistent with the criteria for the diagnosis of BWS. CONCLUSION(S): Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.