Literature DB >> 20338511

Opening the TRPML gates.

Soichiro Yamaguchi1, Shmuel Muallem.   

Abstract

The intracellular TRPML channels have multiple biological roles, but the physiological stimuli that open them remained unknown. In a previous issue of Chemistry & Biology, Grimm et al. report a high-throughput chemical screen that identified a plethora of selective activators of TRPML3 that should open the way to fully characterize these channels and their physiological roles. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2010        PMID： 20338511      PMCID： PMC2857704          DOI： 10.1016/j.chembiol.2010.02.009

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  13 in total

1.  Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.

Authors:  Kartik Venkatachalam; Thomas Hofmann; Craig Montell
Journal:  J Biol Chem       Date:  2006-04-10       Impact factor: 5.157

2.  Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype.

Authors:  Hyun Jin Kim; Qin Li; Sandra Tjon-Kon-Sang; Insuk So; Kirill Kiselyov; Shmuel Muallem
Journal:  J Biol Chem       Date:  2007-10-25       Impact factor: 5.157

3.  Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.

Authors:  Federica Di Palma; Inna A Belyantseva; Hung J Kim; Thomas F Vogt; Bechara Kachar; Konrad Noben-Trauth
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-25       Impact factor: 11.205

4.  Small molecule activators of TRPML3.

Authors:  Christian Grimm; Simone Jörs; S Adrian Saldanha; Alexander G Obukhov; Bifeng Pan; Kazuo Oshima; Math P Cuajungco; Peter Chase; Peter Hodder; Stefan Heller
Journal:  Chem Biol       Date:  2010-02-26

5.  Identification of the gene causing mucolipidosis type IV.

Authors:  R Bargal; N Avidan; E Ben-Asher; Z Olender; M Zeigler; A Frumkin; A Raas-Rothschild; G Glusman; D Lancet; G Bach
Journal:  Nat Genet       Date:  2000-09       Impact factor: 38.330

6.  Development of monovalent ions in the endolymph in mouse cochlea.

Authors:  M Yamasaki; S Komune; M Shimozono; K Matsuda; A Haruta
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  2000 Sep-Oct       Impact factor: 1.538

Review 7.  Transient receptor potential cation channels in disease.

Authors:  Bernd Nilius; Grzegorz Owsianik; Thomas Voets; John A Peters
Journal:  Physiol Rev       Date:  2007-01       Impact factor: 37.312

8.  Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesis.

Authors:  Sebastian Treusch; Sarah Knuth; Susan A Slaugenhaupt; Ehud Goldin; Barth D Grant; Hanna Fares
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-15       Impact factor: 11.205

9.  A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse.

Authors:  Christian Grimm; Math P Cuajungco; Alexander F J van Aken; Michael Schnee; Simone Jörs; Corné J Kros; Anthony J Ricci; Stefan Heller
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-28       Impact factor: 11.205

10.  The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy.

Authors:  Hyun Jin Kim; Abigail A Soyombo; Sandra Tjon-Kon-Sang; Insuk So; Shmuel Muallem
Journal:  Traffic       Date:  2009-05-11       Impact factor: 6.215
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  3 in total

1.  Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.

Authors:  Christian Grimm; Simone Jörs; Zhaohua Guo; Alexander G Obukhov; Stefan Heller
Journal:  J Biol Chem       Date:  2012-06-29       Impact factor: 5.157

2.  Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.

Authors:  Eva Plesch; Cheng-Chang Chen; Elisabeth Butz; Anna Scotto Rosato; Einar K Krogsaeter; Hua Yinan; Karin Bartel; Marco Keller; Dina Robaa; Daniel Teupser; Lesca M Holdt; Angelika M Vollmar; Wolfgang Sippl; Rosa Puertollano; Diego Medina; Martin Biel; Christian Wahl-Schott; Franz Bracher; Christian Grimm
Journal:  Elife       Date:  2018-11-27       Impact factor: 8.140

Review 3.  TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells.

Authors:  Dennis Clement; Jodie P Goodridge; Christian Grimm; Sandip Patel; Karl-Johan Malmberg
Journal:  Front Immunol       Date:  2020-04-28       Impact factor: 7.561
  3 in total

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