Christina Davidson1, Manju Monga, Dayna Ellison, Alex Vidaeff. 1. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine, 1709 Dryden Road, Suite 1100, Houston, TX 77030, USA. cmdavids@bcm.edu
Abstract
OBJECTIVE: To determine the duration of continuing pregnancy after antenatal corticosteroid (AC) administration and to evaluate the potential opportunity for rescue AC. STUDY DESIGN: Retrospective analysis of women at 24-32 weeks' gestation who received AC at one institution. RESULTS: Six hundred ninety-two women received AC. Two hundred forty-seven (35.7%) delivered at > or = 34 weeks' gestation. Three hundred twenty-one (46.4%) delivered within 1 week of AC; 92 of those women (13.3%) delivered within 24 hours. Only 124 (17.9%) remained pregnant 1 week after AC and delivered at < 34 weeks. The latter were compared to women delivering > 2 week after AC but > or = 34 weeks. More likely to deliver at < 34 weeks were those women who received AC for premature preterm rupture of membranes (OR 3.83, 95% CI 2.06-7.17), twins (OR 2.90, 95% CI 1.42-5.95) or before 28 weeks (OR 2.21, 95% CI 1.38-3.52). CONCLUSION: Rescue AC may apply to only 18% of cases, and we identified subsets of more likely candidates.
OBJECTIVE: To determine the duration of continuing pregnancy after antenatal corticosteroid (AC) administration and to evaluate the potential opportunity for rescue AC. STUDY DESIGN: Retrospective analysis of women at 24-32 weeks' gestation who received AC at one institution. RESULTS: Six hundred ninety-two women received AC. Two hundred forty-seven (35.7%) delivered at > or = 34 weeks' gestation. Three hundred twenty-one (46.4%) delivered within 1 week of AC; 92 of those women (13.3%) delivered within 24 hours. Only 124 (17.9%) remained pregnant 1 week after AC and delivered at < 34 weeks. The latter were compared to women delivering > 2 week after AC but > or = 34 weeks. More likely to deliver at < 34 weeks were those women who received AC for premature preterm rupture of membranes (OR 3.83, 95% CI 2.06-7.17), twins (OR 2.90, 95% CI 1.42-5.95) or before 28 weeks (OR 2.21, 95% CI 1.38-3.52). CONCLUSION: Rescue AC may apply to only 18% of cases, and we identified subsets of more likely candidates.
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